Biocompatibility and Hemolytic Activity Studies of Synthesized Alginate-Based Polyurethanes

• Published in: Polymers Vol. 14; no. 10; p. 2091
• Main Authors: Zafar, Kashif, Zia, Khalid Mahmood, Alzhrani, Rami M, Almalki, Atiah H, Alshehri, Sameer
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20-05-2022; MDPI
• Subjects: Acids; Algae; alginate; Alginates; Biocompatibility; biopolymer; Biopolymers; Butanediol; Chemical reactions; Composite materials; Condensation polymerization; Contact angle; Crystal structure; Crystallinity; Functional groups; Hexamethylene diisocyanate; Inflammation; Mechanical properties; NMR spectroscopy; Polymer blends; Polymers; Polyurethane; polyurethane composites; Polyurethane resins; Sodium; Spectrum analysis; Tensile strength; Thermal stability; Transplants & implants; Viscosity; Water absorption; Wound healing; X-ray diffraction; alginate; biopolymer; polyurethane composites
• ISSN: 2073-4360; 2073-4360
• DOI: 10.3390/polym14102091

Many investigators have focused on the development of biocompatible polyurethanes by chemical reaction of functional groups contained in a spacer and introduced in the PU backbone or by a grafting method on graft polymerization of functional groups. In this study, alginate-based polyurethane (PU) composites were synthesized via step-growth polymerization by the reaction of hydroxyl-terminated polybutadiene (HTPB) and hexamethylene diisocyanate (HMDI). The polymer chains were further extended with blends of 1,4-butanediol (1,4-BDO) and alginate (ALG) with different mole ratios. The structures of the prepared PU samples were elucidated with FTIR and
H NMR spectroscopy. The crystallinity of the prepared samples was evaluated with the help of X-ray diffraction (XRD). The XRD results reveal that the crystallinity of the PU samples increases when the concentration of alginate increases. Thermogravimetric (TGA) results show that samples containing a higher amount of alginate possess higher thermal stability. ALG-based PU composite samples show more biocompatibility and less hemolytic activity. Mechanical properties, contact angle, and water absorption (%) were also greatly affected.