Effects of IL-6 Polymorphisms on Individual Susceptibility to Allergic Diseases: A Systematic Review and Meta-Analysis

• Published in: Frontiers in genetics Vol. 13; p. 822091
• Main Authors: Yang, Ying, Xiao, Jingxin, Tang, Lingling, Wang, Bohan, Sun, Xianhong, Xu, Zhongchi, Liu, Li, Shi, Suofang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 16-03-2022
• Subjects: allergic asthma; allergic diseases; allergic rhinitis; Genetics; IL-6; meta-analysis; polymorphism; allergic asthma; meta-analysis; atopic dermatitis; polymorphism; allergic rhinitis; IL-6; allergic diseases
• ISSN: 1664-8021; 1664-8021
• DOI: 10.3389/fgene.2022.822091

Many studies have assessed the potential link between
polymorphisms and susceptibility to allergic diseases. However, the results are still conflicting. Therefore, a comprehensive meta-analysis can not only resolve differences but also provide clues for future projects.
A systematic electronic search was conducted on the databases of Web of Science, PubMed, and Cochrane Library to retrieve all published studies. Revman and Stata software were used for statistical analysis.
This meta-analysis included 11 studies. The results revealed that there was a statistically significant association between
rs1800795 polymorphism and the risk of asthma and allergic rhinitis in the general population. Subgroup analyses demonstrated that rs1800795 affected allergic diseases risk in different populations.
Our findings suggested that
rs1800795 was associated with allergic diseases susceptibility among Asians and Caucasians in opposite trends, and it might influence the risk of asthma and allergic rhinitis. None of the
polymorphisms were shared risk variants of allergic diseases.