Takotsubo cardiomyopathy caused by infusion reaction to trastuzumab

• Published in: International cancer conference journal Vol. 9; no. 1; pp. 28 - 31
• Main Authors: Matsumoto, Toshihiko, Oda, Takashi, Yoshida, Yu, Kimura, Shogo, Himei, Hitomi, Tsuduki, Takao, Takagi, Shinjiro, Takatani, Masahiro, Morishita, Hirofumi
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01-01-2020; Springer Nature B.V
• Subjects: Breast cancer; Cardiomyopathy; Cardiotoxicity; Case Report; Case reports; Chemotherapy; Consent; Creatinine; Drug dosages; Ejection fraction; EKG; Electrocardiography; Gastric cancer; Growth factors; Heart failure; Ischemia; Medical imaging; Medicine; Medicine & Public Health; Oncology; Patients; Surgical Oncology; Trastuzumab; Troponin I; Ultrasonic imaging; Ventricle; Infusion reaction; Chemotherapy; Takotsubo cardiomyopathy
• ISSN: 2192-3183; 2192-3183
• DOI: 10.1007/s13691-019-00396-0

Takotsubo cardiomyopathy (TCM) is also known as stress-induced cardiomyopathy. The occurrence of TCM due to infusion reaction is extremely rare. A 65-year-old man began receiving trastuzumab monotherapy for gastric cancer. However, he developed an infusion reaction after administration. Electrocardiography revealed negative T waves, ST segment elevation, and apical akinesis and hypokinesis of the left ventricle with apical ballooning in the systole and diastole. Furthermore, troponin I and creatinine kinase (CK) levels and CK-myocardial band were elevated. Based on these findings, he was diagnosed with TCM. This is the first report of TCM due to an infusion reaction.