Epigenetic changes in diabetes

The incidence of diabetes is increasing worldwide. Diabetes is quickly becoming one of the leading causes of death. Diabetes is a genetic disease; however, the environment plays critical roles in its development and progression. Epigenetic changes often translate environmental stimuli to changes in...

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Bibliographic Details
Published in:	Neuroscience letters Vol. 625; pp. 64 - 69
Main Authors:	Al-Haddad, Rami, Karnib, Nabil, Assaad, Rawad Abi, Bilen, Yara, Emmanuel, Nancy, Ghanem, Anthony, Younes, Joe, Zibara, Victor, Stephan, Joseph S., Sleiman, Sama F.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 20-06-2016
Subjects:	Animals Diabetes Diabetes Mellitus - genetics DNA Methylation Epigenesis, Genetic Epigenetics Gene Expression Regulation HDACs Histone Code Humans RNA, Untranslated - genetics Epigenetics DNA methylation HDACs Diabetes
Online Access:	Get full text
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Summary:	The incidence of diabetes is increasing worldwide. Diabetes is quickly becoming one of the leading causes of death. Diabetes is a genetic disease; however, the environment plays critical roles in its development and progression. Epigenetic changes often translate environmental stimuli to changes in gene expression. Changes in epigenetic marks and differential regulation of epigenetic modulators have been observed in different models of diabetes and its associated complications. In this minireview, we will focus DNA methylation, Histone acetylation and methylation and their roles in the pathogenesis of diabetes.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0304-3940 1872-7972
DOI:	10.1016/j.neulet.2016.04.046