Steroids and statins: an old and a new anti-inflammatory strategy compared

• Published in: Perfusion Vol. 26; no. 1; pp. 31 - 37
• Main Authors: Vukovic, Petar M, Maravic-Stojkovic, Vera R, Peric, Miodrag S, Jovic, Miomir Dj, Cirkovic, Milan V, Gradinac, Sinisa Dj, Djukanovic, Bosko P, Milojevic, Predrag S
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01-01-2011; Sage Publications Ltd
• Subjects: Anti-Inflammatory Agents - therapeutic use; Atorvastatin Calcium; Female; Heptanoic Acids - therapeutic use; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Male; Methylprednisolone - therapeutic use; Middle Aged; Pyrroles - therapeutic use; Treatment Outcome; Ventricular Dysfunction, Left - drug therapy; cardiopulmonary bypass; inflammation; drugs; statins
• ISSN: 0267-6591; 1477-111X
• DOI: 10.1177/0267659110385607

Objectives: This study compared the anti-inflammatory effects of methylprednisolone (MP) and atorvastatin and analysed their influences on clinical variables in patients undergoing coronary revascularization.
Methods: Ninety patients with compromised left ventricular ejection fraction (≤30%) undergoing elective coronary surgery were equally randomized to one of three groups: statin group, treatment with atorvastatin (20 mg/day) 3 weeks before surgery; methylprednisolone group, a single shot of methylpredniosolone (10mg/kg); and control group.
Results: Postoperative IL-6 was higher in the control group when compared to the methylprednisolone and statin groups (p<0.01). IL-6 was higher in the statin-treated patients (p<0.05 versus methylprednisolone). Administration of methylprednisolone as well as statin treatment increased postoperative cardiac index, left ventricular stroke work index, decreased postoperative atrial fibrilation rate and reduced ICU stay (p<0.05 versus control). The number of patients requiring inotropic support was lower in the methylprednisolone group when compared with the other two groups (p<0.01). Tracheal intubation time was reduced in patients who received methylprednisolone (p<0.01 versus control).
Conclusions: Preoperative administration of either methylprednisolone or atorvastatin reduced pro-inflammatory cytokine release, improved haemodynamics, decreased postoperative atrial fibrilation rate and reduced ICU stay in patients with significantly impaired cardiac function undergoing coronary revascularization. Treatment with methylprednisolone was associated with less inotropic support requirements and reduced mechanical ventilation time.