Natural antibody response to Plasmodium falciparum Exp‐1, MSP‐3 and GLURP long synthetic peptides and association with protection

• Published in: Parasite immunology Vol. 26; no. 6‐7; pp. 265 - 272
• Main Authors: Meraldi, V., Nebié, I., Tiono, A. B., Diallo, D., Sanogo, E., Theisen, M., Druilhe, P., Corradin, G., Moret, R., Sirima, B. S.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01-06-2004
• Subjects: Animals; Antibodies, Protozoan - blood; antibody; Antigens, Protozoan - immunology; Burkina Faso; Child; Child, Preschool; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin G - blood; Infant; Longitudinal Studies; longitudinal study; malaria; Malaria, Falciparum - immunology; Malaria, Falciparum - prevention & control; Male; Oligopeptides - immunology; Plasmodium falciparum; Plasmodium falciparum - immunology; Protozoan Proteins - immunology; synthetic peptide; vaccine; Burkina Faso
• ISSN: 0141-9838; 1365-3024
• DOI: 10.1111/j.0141-9838.2004.00705.x

SUMMARY
A longitudinal study was undertaken in Burkina Faso among 293 children aged 6 months to 9 years in order to determine the correlation between an antibody response to several individual malarial antigens and malarial infection. It was found that the presence of a positive antibody response at the beginning of the rainy season to three long synthetic peptides corresponding to Plasmodium falciparum Exp‐1 101–162, MSP‐3 154–249 and GLURP 801–920 but not to CSP 274–375 correlated with a statistically significant decrease in malarial infection during the ongoing transmission season. The simultaneous presence of an antibody response to more than one antigen is indicative of a lower frequency of malarial infection. This gives scientific credibility to the notion that a successful malaria vaccine should contain multiple antigens.