Neuropeptide Y Receptor Genes on Human Chromosome 4q31–q32 Map to Conserved Linkage Groups on Mouse Chromosomes 3 and 8

• Published in: Genomics (San Diego, Calif.) Vol. 41; no. 3; pp. 498 - 500
• Main Authors: Lutz, C.M., Frankel, W.N., Richards, J.E., Thompson, D.A.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01-05-1997; Elsevier
• Subjects: Animals; Base Sequence; Biological and medical sciences; Chromosome Mapping; Chromosomes, Artificial, Yeast; Chromosomes, Human, Pair 4 - genetics; Classical genetics, quantitative genetics, hybrids; Conserved Sequence; Crosses, Genetic; DNA - genetics; Evolution, Molecular; Female; Fundamental and applied biological sciences. Psychology; Genetic Linkage; Genetics of eukaryotes. Biological and molecular evolution; Humans; Male; Mice; Mice, Inbred C57BL; Muridae; Receptors, Neuropeptide Y - genetics; Species Specificity; Vertebrata; Genetic mapping; Neuropeptide Y; Peptide hormone; Rodentia; Chromosome 3; Neuropeptide; Vertebrata; Mammalia; Gene; Mouse; Linkage group; Chromosome 8; Multigene family; Hormonal receptor
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1006/geno.1997.4698

Npy1randNpy2r,the genes encoding mouse type 1 and type 2 neuropeptide Y receptors, have been mapped by interspecific backcross analysis. Previous studies have localized the human genes encoding these receptors to chromosome 4q31–q32. We have now assignedNpy1randNpy2rto conserved linkage groups on mouse Chr 8 and Chr 3, respectively, which correspond to the distal region of human chromosome 4q. Using yeast artificial chromosomes, we have estimated the distance between the human genes to be approximately 6 cM. Although ancient tandem duplication events may account for some closely spaced G-protein-coupled receptor genes, the large genetic distance between the human type 1 and type 2 neuropeptide Y receptor genes raises questions about whether this mechanism accounts for their proximity.