Heterocyclic Organic Compounds as a Fluorescent Chemosensor for Cell Imaging Applications: A Review

• Published in: Critical reviews in analytical chemistry Vol. 54; no. 7; pp. 2538 - 2553
• Main Authors: Mohammad Abu-Taweel, Gasem, Alharthi, Salman S., Al-Saidi, Hamed M., Babalghith, Ahmad O., Ibrahim, Munjed M., Khan, Sikandar
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 02-10-2024; Taylor & Francis Ltd
• Subjects: Aluminum; Analgesics; anti-cancer; Antihypertensives; Antiparasitic agents; Carbon dioxide; Cations; Chemical sensors; Chemoreceptors; chemosensor; Cobalt; Cost analysis; Fluorescence; Fluorometric; Fungicides; heterocyclic; Lead; Medical imaging; Metal ions; Organic compounds; Palladium; Photoluminescence; Photons; Zinc; heterocyclic; photoluminescence; anti-cancer; Fluorometric; chemosensor
• ISSN: 1040-8347; 1547-6510; 1547-6510
• DOI: 10.1080/10408347.2023.2186695

Fluorometric determination of different biologically, industrially, and environmentally important analytes is a powerful technique because this technique has excellent selectivity, high sensitivity, rapid photoluminescence response, low cost, applicability to bioimaging, and low detection limit. Fluorescence imaging is a powerful technique for screening different analytes in the living system. Heterocyclic organic compounds have been extensively used as a fluorescence chemosensor for the determination of different biologically important cations like Co
2+
, Zn
2+
, Cu
2+
, Hg
2+
, Ag
+
, Ni
2+
, Cr
3+
, Al
3+
, Pd
2+
, Fe
3+
Pt
2+
, Mn
2+
, Sn
2+
, Pd
2+
, Au
3+
, Pd
2+
, Cd
2+
, Pb
2+
and other ions in biological and environmental systems. These compounds also showed significant biological applications such as anti-cancer, anti-ulcerogenic, antifungal, anti-inflammatory, anti neuropathic, antihistaminic, antihypertensive, analgesic, antitubercular, antioxidant, antimalarial, antiparasitic, antiglycation, antiviral anti-obesity, and antibacterial potency. In this review, we summarize the heterocyclic organic compounds based on fluorescent chemosensors and their applications in bioimaging studies for the recognition of different biologically important metal ions.