Medicinal Importance and Chemosensing Applications of Pyridine Derivatives: A Review

• Published in: Critical reviews in analytical chemistry Vol. 54; no. 3; pp. 599 - 616
• Main Authors: Mohammad Abu-Taweel, Gasem, Ibrahim, Munjed M., Khan, Sikandar, Al-Saidi, Hamed M., Alshamrani, Meshal, Alhumaydhi, Fahad A., Alharthi, Salman S.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 02-04-2024; Taylor & Francis Ltd
• Subjects: Analgesics; Analytical chemistry; Anions; Anticancer; Anticancer properties; Anticonvulsants; antifungal; Antitumor activity; Cations; Chemical sensors; Chemoreceptors; chemosensor; Fungicides; Heterocyclic compounds; Inflammation; pyridine; Pyridines; Structural analysis; pyridine; antifungal; cations; Anticancer; chemosensor
• ISSN: 1040-8347; 1547-6510; 1547-6510
• DOI: 10.1080/10408347.2022.2089839

Pyridine derivatives are the most common and significant heterocyclic compounds, which play an important role in various fields ranging from medicinal to chemosensing applications. Pyridine derivatives possess different biological activities such as antifungal, antibacterial, antioxidant, antiglycation, analgesic, antiparkinsonian, anticonvulsant, anti-inflammatory, ulcerogenic, antiviral, and anticancer activity. Furthermore, these derivatives have a high affinity for various ions and neutral species and can be used as a highly effective chemosensor for the determination of different species. In this review article, generally used synthetic routes of pyridine, structural characterization, medicinal applications, and potential of pyridine derivatives in analytical chemistry as chemosensors have been discussed. We hope this study will support the new thoughts to design biological active compounds and highly selective and effective chemosensors for the detection of various species (anions, cations, and neutral species) in various samples (environmental, agricultural, and biological).