Fluorescence diffuse optical tomography for free-space and multifluorophore studies

We present two major advances in preclinical fluorescence-enhanced diffuse optical tomography (fDOT) system and assess its performance. It is now possible to perform experiments without adaptation liquid or a glass plate over the animal, and our system is equipped with a filter wheel in order to dis...

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Bibliographic Details
Published in:	Journal of Biomedical Optics Vol. 15; no. 1; p. 016016
Main Authors:	Koenig, Anne, Herv, Lionel, Gonon, Georges, Josserand, Vronique, Berger, Michel, Dinten, Jean-Marc, Boutet, Jerome, Pelti, Philippe, Coll, Jean-Luc, Rizo, Philippe
Format:	Journal Article
Language:	English
Published:	United States 01-01-2010
Subjects:	Animals Biomedical materials Diffusion Female Fluorescent Dyes - chemistry Image Processing, Computer-Assisted - methods In vivo testing In vivo tests Lasers Liquids Mammary Neoplasms, Experimental - pathology Mice Mice, Nude Phantoms, Imaging Reproducibility of Results Surgical implants Tomography Tomography, Optical - methods Whole Body Imaging - methods
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Summary:	We present two major advances in preclinical fluorescence-enhanced diffuse optical tomography (fDOT) system and assess its performance. It is now possible to perform experiments without adaptation liquid or a glass plate over the animal, and our system is equipped with a filter wheel in order to discriminate two injected fluorophores. Evaluation carried out on characterization phantoms and on mice demonstrates enriched use of the system for biological studies on small animals.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	1083-3668 1560-2281
DOI:	10.1117/1.3309738