Prefluostatin and New Urauchimycin Derivatives Produced by Streptomycete Isolates

• Published in: Zeitschrift für Naturforschung. B, A journal of chemical sciences Vol. 61; no. 3; pp. 320 - 325
• Main Authors: Yao, C. B. Fondja, Schiebel, M., Helmke, E., Anke, H., Laatsch, H.
• Format: Journal Article
• Language: English
• Published: Verlag der Zeitschrift für Naturforschung 01-03-2006
• Subjects: Antimycin; Kinamycin; Marine Streptomycetes; Prefluostatin; Urauchimycin
• ISSN: 0932-0776; 1865-7117
• DOI: 10.1515/znb-2006-0312

Guided by chemical screening, two new members of the antimycin group, urauchimycin C (1b) and D (1a), were isolated from the marine-derived Streptomyces sp. isolate B1751 and from a terrestrial strain AdM21, together with prefluostatin (2), a new natural derivative of isoprekinamycin (4). Their structures were established on the basis of NMR data and by comparison with known compounds. In the agar diffusion test, urauchimycin C (1b) and D (1a) were antibiotically inactive against some bacteria and fungi at a concentration of 25 μg per paper disk, while the isoprekinamycin derivative 2 showed weak cytotoxicity and moderate activity in the agar diffusion test against Bacillus subtilis, Mucor miehei, Escherichia coli and Staphylococcus aureus at concentrations of 20 μg per paper disk.