Dermatomyositis and esophageal cancer

• Published in: Southern medical journal (Birmingham, Ala.) Vol. 99; no. 7; pp. 777 - 779
• Main Authors: Iftikhar, Imran, Abdelmannan, Dima, Daw, Hamed A
• Format: Journal Article
• Language: English
• Published: United States Southern Medical Association 01-07-2006
• Subjects: Adenocarcinoma - complications; Adenocarcinoma - diagnosis; Case studies; Corticosteroids; Deglutition Disorders - etiology; Dermatomyositis; Dermatomyositis - complications; Dermatomyositis - diagnosis; Diagnosis; Drug therapy; Esophageal cancer; Esophageal Neoplasms - complications; Esophageal Neoplasms - diagnosis; Humans; Male; Medical research; Medicine, Experimental; Middle Aged; Muscle Weakness - etiology; Southern United States
• ISSN: 0038-4348
• DOI: 10.1097/01.smj.0000215732.28409.af

A case of dermatomyositis and esophageal cancer is described.
A 58-year-old male recently diagnosed with esophageal cancer was admitted to the hospital with complaints of progressive dysphagia, generalized muscle weakness and skin rash. The weakness started symmetrically in the proximal limb muscles. He also developed a characteristic skin rash on the eyelids, the upper chest and around the nails that was thought to be most indicative of dermatomyositis. Creatine kinase, aspartate aminotransferase and aldolase were elevated. A muscle biopsy showed various degrees of degeneration with perivascular interstitial infiltration of lymphoplasma cells, a finding consistent with "dermatomyositis." The patient was started on corticosteroids and within two weeks, his muscle strength was found to be markedly improved and the rash almost disappeared.
Dysphagia can be the presenting symptom of both dermatomyositis and esophageal cancer. In the setting of an underlying malignancy, these symptoms can be misleading and one can miss the diagnosis of dermatomyositis. However, recognition of the characteristic skin rash may provide a clue to the diagnosis. Another aspect of our case that is worth acknowledgment is the quick response to treatment with corticosteroids.