Histamine in pericarditis of children with congenital heart malformations

• Published in: Inflammation research Vol. 59; no. 2; pp. 259 - 261
• Main Authors: Maslińska, D, Laure-Kamionowska, M, Rzodkiewicz, P, Lukasik-Wojtecka, E, Szukiewicz, D, Karolczak, M, Masliński, S
• Format: Journal Article
• Language: English
• Published: Basel Basel : SP Birkhäuser Verlag Basel 01-03-2010; SP Birkhäuser Verlag Basel; Springer Nature B.V
• Subjects: Allergology; Biomarkers, Tumor - biosynthesis; Biomarkers, Tumor - genetics; Biomedical and Life Sciences; Biomedicine; Child, Preschool; Congenital heart malformations; Dermatology; Heart Defects, Congenital - complications; Heart Defects, Congenital - metabolism; Heart Defects, Congenital - pathology; histamine; Histamine - blood; Humans; Immunohistochemistry; Immunology; Infant; Neurology; Pericardial Effusion - metabolism; Pericarditis - etiology; Pericarditis - metabolism; Pericarditis - pathology; pericardium; Pericardium - metabolism; Pericardium - pathology; Pharmacology/Toxicology; Receptors, G-Protein-Coupled - biosynthesis; Receptors, G-Protein-Coupled - genetics; Receptors, Histamine - biosynthesis; Receptors, Histamine - genetics; Receptors, Histamine H4; Reverse Transcriptase Polymerase Chain Reaction; Rheumatology; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Short Communication; Histamine; Congenital heart malformations; Pericardium
• ISSN: 1023-3830; 1420-908X
• DOI: 10.1007/s00011-009-0121-8

Introduction Congenital heart malformations are risk factors that make children susceptible to infections resulting in inflammation. Material and methods The concentration of histamine as a modulator of inflammation was quantified in pericardial fluid and expression of histamine H₄ receptor (H₄R) and histamine-releasing factor (HRF) was determined at mRNA and protein levels. Samples of pericardium and pericardial fluid were obtained during cardiac reconstruction surgery in children. Results In children with pericarditis, increased levels of histamine were found and expression of H₄R was localized on mast cells. Expression of HRF was independent of presence or absence of inflammation in pericardium and was localized within stationary epithelial cells. Conclusion Results indicate that involvement of H4R in pericardial inflammation depends on penetration of mast cells into inflamed tissue, but HRF may not be directly involved in inflammatory reaction of the pericardium.