Four new phenolic compounds from the fruit of Cornus officinalis (Cornaceae) and their anti-inflammatory activity in RAW 264.7 cells

• Published in: Natural product research Vol. 36; no. 15; pp. 3806 - 3812
• Main Authors: Thu, Nguyen Thi, The Hung, Nguyen, Thuy An, Nguyen Thi, Vinh, Le Ba, Binh, Bui Thi, Thu, Nguyen Thi Bich, Khoi, Nguyen Minh, Ha, Do Thi
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01-08-2022; Taylor & Francis Ltd
• Subjects: anti-inflammation; Anti-inflammatory agents; Chromatography; Cornaceae; Cornus officinalis; coroffesters A-D; Fruits; Inflammation; Ionization; Mass spectrometry; Mass spectroscopy; NMR; Nuclear magnetic resonance; Phenolic compounds; phenolics; Phenols; RAW 264.7 cells; coroffesters A-D; anti-inflammation; Cornaceae; Cornus officinalis; RAW 264.7 cells; phenolics
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2021.1887865

Using various chromatographic methods, four new phenolics, coroffesters A-D (1 − 4) were isolated from the fruit of Cornus officinalis (Cornaceae). Their structures (1 − 4) were elucidated unambiguously by spectroscopic methods such as one- and two-dimensional nuclear magnetic resonance (1 D- and 2 D-NMR) spectroscopy and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). The anti-inflammatory activity of the isolated compounds was also evaluated. All compounds (1 − 4) showed moderate inhibitory activity against NO production in a dose-dependent manner in RAW 264.7 cells.