Associations Between Posterior Communicating Artery Aneurysms and Morphological Characteristics of Surrounding Arteries

• Published in: Frontiers in neurology Vol. 13; p. 874466
• Main Authors: Hao, Weili, Hao, Hong, Ren, Chun-Feng, Wang, Xiangling, Gao, Bulang
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 13-07-2022
• Subjects: angle; internal carotid artery; morphological parameters; Neurology; posterior communicating artery aneurysm; tortuosity
• ISSN: 1664-2295; 1664-2295
• DOI: 10.3389/fneur.2022.874466

Objectives
To explore the associations between posterior communicating artery (PComA) aneurysms and morphological characteristics of arteries upstream of and around the PComA bifurcation site.
Methods
In this study, fifty-seven patients with PComA aneurysms and sixty-two control subjects without aneurysms were enrolled. The centerlines of the internal carotid artery (ICA) and important branches were generated for the measurement and analysis of morphological parameters, such as carotid siphon types, diameters of two fitting circles, and the angle formed by them (D
1
, D
2
, and ϕ), length (L) and tortuosity (T
L
) of ICA segment between an ophthalmic artery and PComA bifurcations, bifurcation angle (θ), tortuosity (T
ICA
and T
PComA
), and flow direction changes (θ
ICA
and θ
PComA
) around the PComA bifurcation site.
Results
No significant difference (
p
> 0.05) was found in the siphon types (
p
= 0.467) or L (
p
= 0.114). Significant differences (
p
< 0.05) were detected in D
1
(
p
= 0.036), T
L
(
p
< 0.001), D
2
(
p
= 0.004), ϕ (
p
= 0.008), θ (
p
= 0.001), T
ICA
(
p
< 0.001), T
PComA
(
p
= 0.012), θ
ICA
(
p
< 0.001), and θ
PComA
(
p
< 0.001) between the two groups. T
ICA
had the largest area under the curve (
AUC
) (0.843) in the receiver operating characteristic (
ROC
) analysis in diagnosing the probability of PComA aneurysms presence and was identified as the only potent morphological parameter (
OR
= 11.909) associated with PComA aneurysms presence.
Conclusions
The high tortuosity of the ICA segment around the PComA bifurcation is associated with PComA aneurysm presence.