Comparative immunoprofile of polymorphous low-grade adenocarcinoma and canalicular adenoma

• Published in: Annals of diagnostic pathology Vol. 7; no. 5; pp. 278 - 280
• Main Authors: Furuse, Cristiane, Tucci, Renata, Machado de Sousa, Suzana O, Rodarte Carvalho, Yasmin, Cavalcanti de Araújo, Vera
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-10-2003
• Subjects: Adenocarcinoma - chemistry; Adenocarcinoma - pathology; Adenoma - chemistry; Adenoma - pathology; Biomarkers, Tumor - analysis; Canalicular adenoma; Humans; Immunohistochemistry; Keratin-7; Keratins - analysis; polymorphous low-grade adenocarcinoma; Salivary Gland Neoplasms - chemistry; Salivary Gland Neoplasms - pathology; Salivary Glands, Minor - chemistry; Salivary Glands, Minor - pathology; vimentin; Vimentin - analysis; polymorphous low-grade adenocarcinoma; vimentin; Canalicular adenoma; immunohistochemistry
• ISSN: 1092-9134; 1532-8198
• DOI: 10.1016/S1092-9134(03)00084-4

Immunohistochemistry is an important tool when dealing with salivary gland neoplasms. Canalicular adenoma and polymorphous low-grade adenocarcinoma may share some histologic characteristics that can cause difficulties in their separation. In the present study, cases of polymorphous low-grade adenocarcinoma and canalicular adenoma were submitted to a panel of antibodies to evaluate the differences in their immunoprofiles. The results obtained showed that, while vimentin is only expressed by polymorphous low-grade adenocarcinoma, CK7 and CK8 are present in both neoplasms. Therefore, vimentin is the best marker to differentiate between these tumors.