Alkylation of 6-thiopurine derivatives by the Mitsunobu reaction

Alkylation of 6-thiopurine derivatives by the Mitsunobu reaction

Alkylation of thiopurine derivatives with alcohols by the Mitsunobu reaction are reported in moderated to good yields. The method was applied in synthesis of number of thiopurine and thiopurine ribosides derivatives.

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids Vol. 42; no. 7; pp. 516 - 526
Main Authors: do Espírito Santo, Rafael Dias, da Silva, Bianca Nascimento Monteiro, Rabi, Jaime A., Pinho, Vagner D.
Format: Journal Article
Language:English
Published: United States Taylor & Francis 2023
Taylor & Francis Ltd
Subjects:
Alcohols
Alkylation
Magnetic Resonance Spectroscopy
Mercaptopurine
Mitsunobu reaction
Thiopurines
thiopurines riboside
thiopurines riboside
Mitsunobu reaction
Thiopurines
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Description
Summary:Alkylation of thiopurine derivatives with alcohols by the Mitsunobu reaction are reported in moderated to good yields. The method was applied in synthesis of number of thiopurine and thiopurine ribosides derivatives.
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content type line 23
ISSN:1525-7770
1532-2335
DOI:10.1080/15257770.2022.2163501