DNA methyltransferase expression differs with proliferation in childhood acute lymphoblastic leukemia

• Published in: Molecular biology reports Vol. 37; no. 5; pp. 2471 - 2476
• Main Authors: Sayin, Derya Beyza, Kürekçi, Emin, Karabulut, Halil Gürhan, Ezer, Üstün, Bökesoy, Isik
• Format: Journal Article
• Language: English
• Published: Dordrecht Dordrecht : Springer Netherlands 01-06-2010; Springer Netherlands; Springer Nature B.V
• Subjects: Adolescent; Animal Anatomy; Animal Biochemistry; Biomedical and Life Sciences; Case-Control Studies; Cell Line, Tumor; Cell Proliferation; Child; Child, Preschool; Deoxyribonucleic acid; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases - genetics; DNA (Cytosine-5-)-Methyltransferases - metabolism; Female; Gene Expression Regulation, Leukemic; Genomics; Histology; Humans; Infant; Leukemia; Life Sciences; Male; Molecular biology; Morphology; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Pediatrics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology; RNA, Messenger - genetics; RNA, Messenger - metabolism; Proliferate Cell Nuclear Antigen; Blast Count; Acute Lymphoblastic Leukemia; Endometrial Carcinoma; AdoMet
• ISSN: 0301-4851; 1573-4978
• DOI: 10.1007/s11033-009-9760-7

DNA methylation is involved in genomic imprinting, tissue and stage specic gene regulation, X chromosome inactivation and especially necessary in normal mammalian development. Methylation of DNA at cytosine base occurs at most CpG islands in the mammalian genome, with exception of CpG islands of gene promoters which are usually unmethylated. [PUBLICATION ABSTRACT[