Recent Advancements in Colorimetric and Fluorescent pH Chemosensors: From Design Principles to Applications

• Published in: Critical reviews in analytical chemistry Vol. 53; no. 6; pp. 1313 - 1373
• Main Authors: Banik, Dipanjan, Manna, Saikat Kumar, Maiti, Anwesha, Mahapatra, Ajit Kumar
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 18-08-2023; Taylor & Francis Ltd
• Subjects: biological and environmental applications; Chemical sensors; Chemoreceptors; Colorimetric and fluorometric; Colorimetry; Endoplasmic reticulum; Fluorescence; Golgi apparatus; Mitochondria; pH chemosensors; pH effects; Probes; Colorimetric and fluorometric; biological and environmental applications; pH chemosensors
• ISSN: 1040-8347; 1547-6510
• DOI: 10.1080/10408347.2021.2023002

Due to the immense biological significance of pH in diverse living systems, the design, synthesis, and development of pH chemosensors for pH monitoring has been a very active research field in recent times. In this review, we summarize the designing strategies, sensing mechanisms, biological and environmental applications of fluorogenic and chromogenic pH chemosensors of the last three years (2018-2020). We categorized these pH probes into seven types based on their applications, including 1) Cancer cell discriminating pH probes; 2) Lysosome targetable pH probes; 3) Mitochondria targetable pH probes; 4) Golgi body targetable pH probes; 5) Endoplasmic reticulum targetable pH probes; 6) pH probes used in nonspecific cell imaging; and 7) pH probes without cell imaging. All these different categories exhibit diverse applications of pH probes in biological and environmental fields.