The peptide molecular links between the central nervous and the immune systems

The central nervous system (CNS) and the immune system were for many years considered as two autonomous systems. Now, the reciprocal connections between them are generally recognized and very well documented. The links are realized mainly by various immuno- and neuropeptides. In the review the influ...

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Bibliographic Details
Published in:	Amino acids Vol. 29; no. 3; pp. 161 - 176
Main Authors:	Siemion, I Z, Kluczyk, A, Cebrat, M
Format:	Journal Article
Language:	English
Published:	Austria Springer Nature B.V 01-11-2005
Subjects:	Amino acids Animals Autonomous Central nervous system Central Nervous System - immunology Central Nervous System - physiology Endorphins Enkephalins Humans Immune system Immune System - physiology Immune systems Joints Links Nervous system Neuropeptides Neurotensin Peptides Peptides - physiology Recognition Substance P Thymus Thymus Gland - physiology
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Summary:	The central nervous system (CNS) and the immune system were for many years considered as two autonomous systems. Now, the reciprocal connections between them are generally recognized and very well documented. The links are realized mainly by various immuno- and neuropeptides. In the review the influence of the following immunopeptides on CNS is presented: tuftsin, thymulin, thymopoietin and thymopentin, thymosins, and thymic humoral factor. On the other side, the activity in the immune system of such neuropeptides as substance P, neurotensin, some neurokinins, enkephalins, and endorphins is discussed.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0939-4451 1438-2199
DOI:	10.1007/s00726-005-0231-8