Normal tissue considerations and dose–volume constraints in the moderately hypofractionated treatment of non-small cell lung cancer

• Published in: Radiotherapy and oncology Vol. 119; no. 3; pp. 423 - 431
• Main Authors: Fleming, Cathy, Cagney, Daniel N, O’Keeffe, Serena, Brennan, Sinead M, Armstrong, John G, McClean, Brendan
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01-06-2016
• Subjects: Brachial Plexus - radiation effects; Carcinoma, Non-Small-Cell Lung - radiotherapy; Dose Fractionation; Dose–volume constraints; DVCs; Esophagus - radiation effects; Heart - radiation effects; Hematology, Oncology and Palliative Medicine; Humans; Hypofractionated; Lung - radiation effects; Lung Neoplasms - radiotherapy; NSCLC; Organs at Risk; Radiotherapy Dosage; Toxicity; DVCs; Dose–volume constraints; NSCLC; Toxicity; Hypofractionated
• ISSN: 0167-8140; 1879-0887
• DOI: 10.1016/j.radonc.2016.03.013

Abstract Hypofractionated radiation therapy (RT) regimes in non-small cell lung cancer (NSCLC) have become increasingly popular with a number of international trials currently underway. The majority of the dose–volume-constraints (DVCs) published in the literature refer to conventional 2 Gy per fraction deliveries. Here relevant organs-at-risk (OARs) are identified and available dose–volume constraint data discussed and summarised for moderately hypofractionated NSCLC regimes. The OARs examined include lung, brachial plexus, heart, oesophagus, airway and spinal cord. Where available the toxicity rates are also reported with all data summarised tabulated to aid its use in the clinic.