Effect of selective inhibitor of thromboxane A2 synthetase on cerebral vasospasm after early surgery

• Published in: Journal of neurosurgery Vol. 61; no. 1; p. 24
• Main Authors: Tani, E, Maeda, Y, Fukumori, T, Nakano, M, Kochi, N, Morimura, T, Yokota, M, Matsumoto, T
• Format: Journal Article
• Language: English
• Published: United States 01-07-1984
• Subjects: Acrylates - therapeutic use; Adult; Aged; Cerebral Angiography; Humans; Intracranial Aneurysm - complications; Intracranial Aneurysm - surgery; Ischemic Attack, Transient - diagnostic imaging; Ischemic Attack, Transient - drug therapy; Methacrylates - therapeutic use; Middle Aged; Rupture, Spontaneous; Subarachnoid Hemorrhage - complications; Subarachnoid Hemorrhage - surgery; Thromboxane-A Synthase - antagonists & inhibitors; Tomography, X-Ray Computed
• ISSN: 0022-3085
• DOI: 10.3171/jns.1984.61.1.0024

The authors report the results of inhibition of thromboxane A2 synthetase in 49 consecutive patients with subarachnoid hemorrhage (SAH). These unselected Grade I to IV patients all had a ruptured aneurysm of the anterior circle of Willis, and were operated on within 72 hours after SAH. Twenty-seven patients were treated postoperatively by an intravenous infusion of sodium (E)-3- [4-(3-pyridylmethyl)-phenyl] -2- propenoate (OKY-1581), a selective inhibitor of thromboxane A2 synthetase, at 5 micrograms/kg/min for 10 to 14 days, and the remaining 22 patients did not receive this drug. Both groups of patients had similar age distribution and preoperative neurological conditions. A suggestive but statistically insignificant improvement was found in postoperative angiographic vasospasm, ischemic symptoms, and overall outcome in the group receiving OKY-1581. The incidence of low-density areas on the postoperative computerized tomography scans was significantly decreased in patients treated with OKY-1581 infusion.