Sexual dimorphism in the murine model of extraparenchymal neurocysticercosis

Sexual dimorphism in the murine model of extraparenchymal neurocysticercosis

Neurocysticercosis is a heterogeneous disease, and the patient’s sex seems to play a role in this heterogeneity. Hosts’ sexual dimorphism in cysticercosis has been largely explored in the murine model of intraperitoneal Taenia crassiceps cysticercosis. In this study, we investigated the sexual dimor...

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Published in:Parasitology research (1987) Vol. 122; no. 9; pp. 2147 - 2154
Main Authors: Moreira, Carlos Alexandre Aguiar, Murayama, Luis Henrique Vallesquino, Martins, Tatiane de Camargo, Oliveira, Vinicius Tadeu, Generoso, Diego, Machado, Vania Maria de Vasconcelos, Batah, Sabrina Setembre, Fabro, Alexandre Todorovic, Bazan, Rodrigo, Zanini, Marco Antônio, Sciutto, Edda, Fleury, Agnès, Hamamoto Filho, Pedro Tadao
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-09-2023
Springer
Springer Nature B.V
Subjects:
Animal models
Biomedical and Life Sciences
Biomedicine
Cysticercosis
Cytokines
Gliosis
Hydrocephalus
Immunohistochemistry
Immunology
Inflammation
Interleukin 10
Magnetic resonance imaging
Medical Microbiology
Microbiology
Neuroimaging
Sexual dimorphism
Subarachnoid space
Neurocysticercosis
Inflammation
Sex dimorphism
Hydrocephalus
Taenia crassiceps
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Summary:Neurocysticercosis is a heterogeneous disease, and the patient’s sex seems to play a role in this heterogeneity. Hosts’ sexual dimorphism in cysticercosis has been largely explored in the murine model of intraperitoneal Taenia crassiceps cysticercosis. In this study, we investigated the sexual dimorphism of inflammatory responses in a rat model of extraparenchymal neurocysticercosis caused by T. crassiceps . T. crassiceps cysticerci were inoculated in the subarachnoid space of Wistar rats (25 females, 22 males). Ninety days later, the rats were euthanized for histologic, immunohistochemistry, and cytokines studies. Ten animals also underwent a 7-T magnetic resonance imaging (MRI). Female rats presented a higher concentration of immune cells in the arachnoid-brain interface, reactive astrogliosis in the periventricular region, in situ pro-inflammatory cytokine (interleukin [IL]-6) and anti-inflammatory cytokine (IL-10), and more intense hydrocephalus on MRI than males. Intracranial hypertension signals were not observed during the observational period. Overall, these results suggest sexual dimorphism in the intracranial inflammatory response that accompanied T. crassiceps extraparenchymal neurocysticercosis.
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ISSN:0932-0113
1432-1955
DOI:10.1007/s00436-023-07913-4