Synthesis and antiaggregant properties of Stabilized analogues of polyunsaturated fatty acid metabolites

• Published in: Bioorganic & medicinal chemistry letters Vol. 12; no. 18; pp. 2511 - 2514
• Main Authors: Hachem, Ali, Roussel, Patrick, Ménager, Eric, Grée, Danielle, Le Floc'h, Yves, Grée, René, Cerletti, Chiara, Rolland, Yves, Simonet, Serge, Verbeuren, Tony
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 16-09-2002; Elsevier
• Subjects: Animals; Biological and medical sciences; Blood. Blood coagulation. Reticuloendothelial system; Cells, Cultured; Fatty Acids, Unsaturated - chemical synthesis; Fatty Acids, Unsaturated - metabolism; Fatty Acids, Unsaturated - pharmacology; Humans; Medical sciences; Pharmacology. Drug treatments; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - chemical synthesis; Platelet Aggregation Inhibitors - metabolism; Platelet Aggregation Inhibitors - pharmacology; Rabbits; Human; Aliphatic compound; Nitrogen heterocycle; Rabbit; Anticoagulant; Lagomorpha; Ketone; In vitro; Antiplatelet agent; HETE; Pyridine derivatives; Vertebrata; Platelet; Mammalia; Structure activity relation; Carboxylic acid; Animal; Benzenic compound; Secondary alcohol; Chemical synthesis; Ethylenic compound
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/S0960-894X(02)00507-3

New aromatic and heteroaromatic analogues of polyunsaturated fatty acid metabolites have been prepared using short and versatile strategies. Preliminary studies of their activity as inhibitors of platelet aggregation are reported.
Synthesis of new structural analogues of 13-HODE and 12-HETE and study of their activity as inhibitors of platelet aggregation.