Models for evaluating glioblastoma invasion along white matter tracts

• Published in: Trends in biotechnology (Regular ed.) Vol. 42; no. 3; pp. 293 - 309
• Main Authors: Li, Yao, Wang, Jun, Song, Si-Rong, Lv, Sheng-Qing, Qin, Jian-hua, Yu, Shi-Cang
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-03-2024; Elsevier Limited
• Subjects: Biocompatibility; Brain; Brain cancer; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; Brain research; brain slice; Brain slice preparation; Brain tumors; Cell adhesion & migration; Cell culture; Cell Line, Tumor; Glioblastoma; Glioblastoma - metabolism; Glioblastoma - pathology; Humans; in vitro; invasion; Mechanical properties; Metastases; microfluidic chip; Microfluidics; Morphology; Nanomaterials; Neoplasm Invasiveness; Optic nerve; Organoids; Proteins; Solid tumors; Stem cells; Substantia alba; Tumor Microenvironment; Tumors; White Matter - metabolism; White Matter - pathology; white matter tracts; models; brain slice; glioblastoma; microfluidic chip; invasion; organoids; in vitro; white matter tracts
• ISSN: 0167-7799; 1879-3096
• DOI: 10.1016/j.tibtech.2023.09.005

Ideal research models are urgently needed to explore the mechanisms of glioma invasion along white matter tracts (WMs), which is a determinant for the therapeutic effect of surgery in patients with glioblastoma multiforme (GBM).Various methods with different characteristics, including nanomaterial models and nerve fiber culture models, simulate tumor and nerve interactions. Furthermore, brain slice, cerebral organoid, and microfluidic chip models can be used to simulate the complicated microenvironmental interaction of GBM invasion along WMs.These in vitro models can also be applied to perineural invasion of peripheral solid tumors, peripheral solid tumor-induced axonogenesis, neurogenesis, and neural reprogramming to study the mechanism of brain metastasis of peripheral solid tumors and the relationship between tumors and nerves.
White matter tracts (WMs) are one of the main invasion paths of glioblastoma multiforme (GBM). The lack of ideal research models hinders our understanding of the details and mechanisms of GBM invasion along WMs. To date, many potential in vitro models have been reported; nerve fiber culture models and nanomaterial models are biocompatible, and the former have electrically active neurons. Brain slice culture models, organoid models, and microfluidic chip models can simulate the real brain and tumor microenvironment (TME), which contains a variety of cell types. These models are closer to the real in vivo environment and are helpful for further studying not only invasion along WMs by GBM, but also perineural invasion and brain metastasis by solid tumors.
White matter tracts (WMs) are one of the main invasion paths of glioblastoma multiforme (GBM). The lack of ideal research models hinders our understanding of the details and mechanisms of GBM invasion along WMs. To date, many potential in vitro models have been reported; nerve fiber culture models and nanomaterial models are biocompatible, and the former have electrically active neurons. Brain slice culture models, organoid models, and microfluidic chip models can simulate the real brain and tumor microenvironment (TME), which contains a variety of cell types. These models are closer to the real in vivo environment and are helpful for further studying not only invasion along WMs by GBM, but also perineural invasion and brain metastasis by solid tumors.