Proadrenomedullin as a prognostic marker in neonatal sepsis

• Published in: Pediatric research Vol. 72; no. 5; pp. 507 - 512
• Main Authors: Oncel, Mehmet Yekta, Dilmen, Ugur, Erdeve, Omer, Ozdemir, Ramazan, Calisici, Erhan, Yurttutan, Sadik, Canpolat, Fuat Emre, Oguz, Serife Suna, Uras, Nurdan
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01-11-2012; Lippincott Williams & Wilkins
• Subjects: 631/250/256/1980; 692/53/2422; 692/700/139; 692/700/1720; Adrenomedullin - blood; Adult; Analysis of Variance; Bacterial diseases; Bacterial sepsis; Biological and medical sciences; Biomarkers - blood; Birth Weight; C-Reactive Protein - metabolism; Case-Control Studies; Chi-Square Distribution; clinical-investigation; Female; General aspects; Gestational Age; Human bacterial diseases; Humans; Infant, Newborn; Infant, Premature; Infectious diseases; Interleukin-6 - blood; Leukocyte Count; Male; Medical sciences; Medicine; Medicine & Public Health; Pediatric Surgery; Pediatrics; Predictive Value of Tests; Prognosis; Protein Precursors - blood; Sensitivity and Specificity; Sepsis - blood; Sepsis - diagnosis; Sepsis - microbiology; Time Factors; Up-Regulation; Young Adult; Human; Infection; Sepsis syndrome; Pediatrics; Neonatal; Newborn; Prognosis; Bacteriosis; Biological marker; Predictive factor; Bacteremia
• ISSN: 0031-3998; 1530-0447
• DOI: 10.1038/pr.2012.106

Background:
Proadrenomedullin (pro-ADM) for the diagnosis of proven and clinical sepsis in a newborn cohort including preterm newborns has not been investigated. We aimed to investigate the value of pro-ADM as a new marker by comparing it with conventional markers in neonatal sepsis (NS).
Methods:
Participants were stratified into three groups; proven sepsis (Group 1a), clinical sepsis (Group 1b), and the control group (Group 2), which consisted of newborns of matched gestational age and birth weight. Sequential measurements of white blood cell count, C-reactive protein (CRP), interleukin-6 (IL-6), and pro-ADM were compared.
Results:
A total of 76 patients with NS (31 with proven sepsis and 45 with clinical sepsis) and 52 healthy controls were enrolled. Mean baseline serum levels of CRP, IL-6, and pro-ADM were significantly higher in both Group 1a and Group 1b as compared with healthy controls (
P
< 0.001 for both). Although mean baseline CRP and IL-6 levels were similar between groups, mean baseline pro-ADM level was higher in the proven sepsis group than in the clinical sepsis group (
P
< 0.001).
Conclusion:
The use of pro-ADM in combination with other acute-phase reactants such as CRP and IL-6 for the diagnosis and follow-up of patients with NS has high sensitivity and specificity.