RNA interference: Promising approach for breast cancer diagnosis and treatment

• Published in: Cell biology international Vol. 47; no. 5; pp. 833 - 847
• Main Authors: Allahyari, Elham, Velaei, Kobra, Sanaat, Zohreh, Jalilzadeh, Nazila, Mehdizadeh, Amir, Rahmati, Mohammad
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01-05-2023
• Subjects: Argonaute 2 protein; Breast cancer; Breast Neoplasms - genetics; Diagnosis; Female; Humans; MicroRNAs - metabolism; miRNA; RNA Interference; RNA, Small Interfering - metabolism; RNA-Induced Silencing Complex - genetics; RNA-Induced Silencing Complex - metabolism; RNA-mediated interference; RNAi; siRNA; breast cancer; miRNA; RNAi; siRNA
• ISSN: 1065-6995; 1095-8355
• DOI: 10.1002/cbin.11979

Today, cancer is one of the main health‐related challenges, and in the meantime, breast cancer (BC) is one of the most common cancers among women, with an alarming number of incidences and deaths every year. For this reason, the discovery of novel and more effective approaches for the diagnosis, treatment, and monitoring of the disease are very important. In this regard, scientists are looking for diagnostic molecules to achieve the above‐mentioned goals with higher accuracy and specificity. RNA interference (RNAi) is a posttranslational regulatory process mediated by microRNA intervention and small interfering RNAs. After transcription and edition, these two noncoding RNAs are integrated and activated with the RNA‐induced silencing complex (RISC) and AGO2 to connect the target mRNA by their complementary sequence and suppress their translation, thus reducing the expression of their target genes. These two RNAi categories show different patterns in different BC types and stages compared to healthy cells, and hence, these molecules have high diagnostic, monitoring, and therapeutic potentials. This article aims to review the RNAi pathway and diagnostic and therapeutic potentials with a special focus on BC.