Mapping the routes of perception: Hemispheric asymmetries in signal propagation dynamics

• Published in: Psychophysiology Vol. 61; no. 6; pp. e14529 - n/a
• Main Authors: Bonfanti, Davide, Mazzi, Chiara, Savazzi, Silvia
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01-06-2024
• Subjects: Adult; Brain Mapping; Cerebral hemispheres; early visual cortex; EEG; Electroencephalography; Evoked Potentials, Visual - physiology; Female; Functional Laterality - physiology; hemispheric asymmetries; Humans; Information processing; interhemispheric differences; Magnetic fields; Male; Phosphenes; Phosphenes - physiology; TMS‐EEG; Transcranial Magnetic Stimulation; visual awareness; Visual Cortex - physiology; Visual perception; Visual Perception - physiology; Visual stimuli; Visual system; Visual thresholds; Young Adult; early visual cortex; interhemispheric differences; visual awareness; hemispheric asymmetries; phosphenes; TMS‐EEG
• ISSN: 0048-5772; 1469-8986; 1540-5958
• DOI: 10.1111/psyp.14529

The visual system has long been considered equivalent across hemispheres. However, an increasing amount of data shows that functional differences may exist in this regard. We therefore tried to characterize the emergence of visual perception and the spatiotemporal dynamics resulting from the stimulation of visual cortices in order to detect possible interhemispheric asymmetries. Eighteen participants were tested. Each of them received 360 transcranial magnetic stimulation (TMS) pulses at phosphene threshold intensity over left and right early visual areas while electroencephalography was being recorded. After each single pulse, participants had to report the presence or absence of a phosphene. Local mean field power analysis of TMS‐evoked potentials showed an effect of both site (left vs. right TMS) of stimulation and hemisphere (ipsilateral vs. contralateral to the TMS): while right TMS determined early stronger activations, left TMS determined later stronger activity in contralateral electrodes. The interhemispheric signal propagation index revealed differences in how TMS‐evoked activity spreads: left TMS‐induced activity diffused contralaterally more than right stimulation. With regard to phosphenes perception, distinct electrophysiological patterns were found to reflect similar perceptual experiences: left TMS‐evoked phosphenes are associated with early occipito‐parietal and frontal activity followed by late central activity; right TMS‐evoked phosphenes determine only late, fronto‐central, and parietal activations. Our results show that left and right occipital TMS elicits differential electrophysiological patterns in the brain, both per se and as a function of phosphene perception. These distinct activation patterns may suggest a different role of the two hemispheres in processing visual information and giving rise to perception.
Our TMS‐EEG study challenges the idea that hemispheric asymmetries only emerge for high‐order cognitive functions. The stimulation of visual areas demonstrates that the interhemispheric signal propagation differs according to the stimulated hemisphere and that phosphene perception in the two hemispheres is sustained by different electrophysiological patterns. This can also lead to potential clinical applications, especially in the diagnostic process.