Monogenic diabetes: A single center experience from South India

• Published in: Pediatric diabetes Vol. 22; no. 1; pp. 75 - 81
• Main Authors: Lakshmanan, Nivethitha Karthika, Pavithran, Praveen V, Bhavani, Nisha, Abraham, Nithya, Kumar, Harish, Nair, Vasantha, Menon, Usha, Menon, Arun S, Narayanan, Prem, Lakshmi, Geetha
• Format: Journal Article
• Language: English
• Published: Former Munksgaard John Wiley & Sons A/S 01-02-2021; Wiley Subscription Services, Inc
• Subjects: Children; Diabetes; Diabetes mellitus (insulin dependent); Diabetes mellitus (non-insulin dependent); Mitochondria; monogenic diabetes; neonatal diabetes mellitus; Neonates; Newborn babies; Patients; Pediatrics; syndromic diabetes; Thiamine; Wolfram syndrome; neonatal diabetes mellitus; syndromic diabetes; Wolfram syndrome; monogenic diabetes
• ISSN: 1399-543X; 1399-5448
• DOI: 10.1111/pedi.13040

Monogenic forms of diabetes in children are frequently misclassified as either type 1 diabetes or young‐onset type 2 diabetes. There is a paucity of literature regarding pediatric monogenic diabetes in the Indian population. A retrospective analysis of case records of 37 children with monogenic diabetes who were diagnosed between 2008 and 2019 in a South Indian tertiary care center was performed. The write‐up describes the clinical, biochemical, and genetic characterization of these patients with the diagnoses of neonatal diabetes mellitus (15 patients), MODY (five patients), and various forms of syndromic diabetes (13 with Wolfram syndrome, two with H syndrome, one with mitochondrial diabetes, and one with thiamine responsive megaloblastic anemia).