Chlorinated dibenzo-p-dioxins and dibenzofurans and the human immune system: 3. Plasma immunoglobulins and cytokines of workers with quantified moderately-increased body burdens

• Published in: Life sciences (1973) Vol. 66; no. 22; pp. 2123 - 2142
• Main Authors: Neubert, Reinhard, Maskow, Lutz, Triebig, Gerhard, Broding, Hans Christian, Jacob-Müller, Ursula, Helge, Hans, Neubert, Diether
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 21-04-2000
• Subjects: Adult; Aged; Benzofurans - toxicity; Body Burden; cytokines; Cytokines - blood; Female; human; Humans; immune system; Immune System - drug effects; Immunoglobulin G - blood; immunoglobulins; Male; Middle Aged; Occupational Exposure; PCDD/PCDF; polychlorinated dibenzo- p-dioxins; Polychlorinated Dibenzodioxins - toxicity; polychlorinated dibenzofurans; Receptors, Cell Surface - analysis; polychlorinated dibenzo- p-dioxins; polychlorinated dibenzofurans; cytokines; immunoglobulins; human; PCDD/PCDF
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/S0024-3205(00)00540-3

The concentrations of immunoglobulins (IgA, IgD, IgG, IgM) and of several cytokines were measured in the plasma of volunteers with clearly, but moderately, increased body burdens of polychlorinated dibenzo-
p-dioxins and dibenzofurans (PCDD/PCDF), using monoclonal antibodies and an enzyme-linked immuno-sorbant assay. Two groups of workers with different body burdens of PCDD/PCDF were studied: (trial I) persons with mainly 2,3,7,8-tetrachlorodibenzo-
p-dioxin (TCDD) and (trial II) persons with mainly penta- and hexachlorinated dibenzofurans (P5CDF/H6CDF) in their blood fat. Including the reference group, 158 volunteers were investigated. A slight but statistically significant decrease was observed in the plasma concentration of IgG1 in persons exposed to TCDD, but not in persons exposed to P5CDF/H6CDF. When the data of both groups were pooled and a multiregression analysis against international TCDD toxicity equivalencies (I-TEq, NATO/CCMS) was performed, taking several confounding factors into account, no influence of the dioxin exposure could be revealedf. There were no changes in the plasma concentrations of the other immunoglobulins studied In the same volunteers, no deviation from the reference range was found for the concentrations of the cytokines: IL-1α, IL-1β, IL-6 and TNFα in blood plasma.