Increasing pancreatic cancer is not paralleled by pancreaticoduodenectomy volumes in Brazil: A time trend analysis

• Published in: Hepatobiliary & pancreatic diseases international Vol. 18; no. 1; pp. 79 - 86
• Main Authors: Perrotta de Souza, Lucila M, Moreira, Jessica PL, Fogaça, Homero S, Eulálio, José Marcus Raso, Luiz, Ronir R, de Souza, Heitor SP
• Format: Journal Article
• Language: English
• Published: Singapore Elsevier B.V 01-02-2019; D'Or Institute for Research and Education, Rio de Janeiro, Brazil; Department of Internal Medicine, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil%Institute of Public Health Studies (IESC), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil%Department of Surgery, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil%Department of Internal Medicine, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
• Subjects: Ecological study; Hospitalization rates; Mortality rates; Pancreatic cancer; Pancreaticoduodenectomy; Time trend analysis; Hospitalization rates; Pancreaticoduodenectomy; Mortality rates; Pancreatic cancer; Time trend analysis; Ecological study
• ISSN: 1499-3872
• DOI: 10.1016/j.hbpd.2018.12.007

Currently, surgical resection represents the only curative treatment for pancreatic cancer (PC), however, the majority of tumors are no longer resectable by the time of diagnosis. The aim of this study was to describe time trends and distribution of pancreaticoduodenectomies (PDs) performed for treating PC in Brazil in recent years.
Data were retrospectively obtained from Brazilian Health Public System (namely DATASUS) regarding hospitalizations for PC and PD in Brazil from January 2008 to December 2015. PC and PD rates and their mortalities were estimated from DATASUS hospitalizations and analyzed for age, gender and demographic characteristics.
A total of 2364 PDs were retrieved. Albeit PC incidence more than doubled, the number of PDs increased only 37%. Most PDs were performed in men (52.2%) and patients between 50 and 69 years old (59.5%). Patients not surgically treated and those 70 years or older had the highest in-hospital mortality rates. The most developed regions (Southeast and South) as well as large metropolitan integrated municipalities registered 76.2% and 54.8% of the procedures, respectively. LMIM PD mortality fluctuated, ranging from 13.6% in 2008 to 11.8% in 2015.
This study suggests a trend towards regionalization and volume-outcome relationships for PD due to PC, as large metropolitan integrated municipalities registered most of the PDs and more stable mortality rates. The substantial differences between PD and PC increasing rates reveals a limiting step on the health system resoluteness. Reduction in the number of hospital beds and late access to hospitalization, despite improvement in diagnostic methods, could at least in part explain these findings.