Effects of the cannabinoid antagonists AM281 and AM630 on deprivation-induced intake in Lewis rats

Male Lewis rats (two groups of 10) received intracerebroventricular injections of either AM 630 (vehicle, 2.5, 5, 10 and 20 μg) or AM 281 (vehicle, 5, 10, 20 and 40 μg) following overnight food deprivation. The CB2 antagonist AM 630 failed to block deprivation-induced intake at 0.5, 1, 2, 4 and 6 h....

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Bibliographic Details
Published in:	Brain research Vol. 967; no. 1; pp. 290 - 292
Main Authors:	Werner, Nikolaus A., Koch, James E.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 28-03-2003
Subjects:	Animals Behavioral pharmacology Cannabinoids - pharmacology CB1 CB2 Eating - drug effects Eating - physiology Food Deprivation - physiology Indoles - pharmacology Ingestion Male Morpholines - pharmacology Pyrazoles - pharmacology Rats Rats, Inbred Lew Receptor, Cannabinoid, CB2 Receptors, Cannabinoid Receptors, Drug - antagonists & inhibitors Receptors, Drug - physiology CB2 Behavioral pharmacology CB1 Neural basis of behavior Ingestion
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Summary:	Male Lewis rats (two groups of 10) received intracerebroventricular injections of either AM 630 (vehicle, 2.5, 5, 10 and 20 μg) or AM 281 (vehicle, 5, 10, 20 and 40 μg) following overnight food deprivation. The CB2 antagonist AM 630 failed to block deprivation-induced intake at 0.5, 1, 2, 4 and 6 h. The CB1 antagonist AM 281 significantly blocked intake following 20 μg (1 h) and 40 μg (1, 2, 4 and 6 h). Results are discussed with respect to cannabinoid receptor systems’ involvement in ingestion and the differential pharmacological profiles of AM 630 and AM 281.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(02)04274-9