Migrating colonic crypt epithelial cells: primary targets for transformation

• Published in: Carcinogenesis (New York) Vol. 23; no. 11; pp. 1777 - 1780
• Main Authors: Lamprecht, Sergio A., Lipkin, Martin
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01-11-2002; Oxford Publishing Limited (England)
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - pathology; Adenoma - genetics; Adenoma - pathology; adenomatous polyposis coli; Adenomatous Polyposis Coli Protein - physiology; Animals; APC; Biological and medical sciences; Cell Movement; Cell physiology; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Cell Transformation, Neoplastic - pathology; Colonic Neoplasms - genetics; Colonic Neoplasms - pathology; Epithelial Cells - cytology; Fundamental and applied biological sciences. Psychology; Genes, APC; Humans; Intestinal Mucosa - cytology; Models, Biological; Molecular and cellular biology; Cell proliferation; Stem cell; Migration; Tumor initiation; Malignant tumor; Cell transformation; Carcinogenesis; Colonic disease; Malignant transformation; Digestive diseases; Intestinal disease; Epithelial cell; Colon; Mutation; Mechanism of action; Tumor suppressor gene
• ISSN: 0143-3334; 1460-2180; 1460-2180
• DOI: 10.1093/carcin/23.11.1777

It is widely believed that stem cells are the relevant target cells for colonic cell transformation. Evidence is presented that a proliferative transit daughter cell acquiring a mutant adenomatous polyposis coli gene during upward migration from the crypt base can develop retention abnormalities and permanence in the crypt, thus qualifying as a transformed clone which is retained in the colonic epithelium.