Nuclear compartments and gene regulation

Improvements in fluorescence microscopy have allowed us to explore the three-dimensional organization of the nucleus in ways that were impossible ten years ago, revealing subdomains or compartments within the nucleus defined by their enrichments of subsets of factors. Correlations have been drawn be...

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Bibliographic Details
Published in:	Current opinion in genetics & development Vol. 9; no. 2; pp. 199 - 205
Main Authors:	Cockell, Moira, Gasser, Susan M
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-04-1999
Subjects:	Animals Cell Nucleus - metabolism Cell Nucleus - ultrastructure Gene Expression Regulation Heterochromatin - genetics Telomere PRE SAR Rap1 FISH Pc-G TPE trx-G Sir
Online Access:	Get full text
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Summary:	Improvements in fluorescence microscopy have allowed us to explore the three-dimensional organization of the nucleus in ways that were impossible ten years ago, revealing subdomains or compartments within the nucleus defined by their enrichments of subsets of factors. Correlations have been drawn between the silencing of a gene and its proximity to a heterochromatic compartment or to the nuclear periphery. The application of genetics and high-resolution microscopy helps examine the creation, maintenance and impact of these compartments on gene expression.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0959-437X 1879-0380
DOI:	10.1016/S0959-437X(99)80030-6