Chlordane compounds and metabolite residues in termite control workers' blood

• Published in: Bulletin of environmental contamination and toxicology Vol. 54; no. 6; pp. 855 - 862
• Main Authors: Jitunari, F. (Kagawa Medical School, Kagawa, Japan.), Asakawa, F, Takeda, N, Suna, S, Manabe, Y
• Format: Journal Article
• Language: English
• Published: New York, NY Springer-Verlag 01-06-1995
• Subjects: Biological and medical sciences; BLOOD; Chlordan - blood; Chlordan - isolation & purification; CHLORDANE; Chromatography, Gas; CLORDANO; CONTROL DE INSECTOS; DIAGNOSIS; DIAGNOSTIC; DIAGNOSTICO; Humans; INSECT CONTROL; INSECTICIDAS; INSECTICIDE; INSECTICIDES; ISOPTERA; Japan; Longitudinal Studies; LUTTE ANTIINSECTE; Medical sciences; METABOLITE; METABOLITES; METABOLITOS; OBREROS; Occupational Exposure; OUVRIER; Pesticides, fertilizers and other agrochemicals toxicology; Reference Standards; RESIDU; RESIDUES; RESIDUOS; SANG; SANGRE; Stereoisomerism; Toxicology; WORKERS; Japan; Human; Biological fluid; Insecticide; Preservative; Metabolite; Wood industry; Occupational exposure; Chlordane; Long term; Blood; Biological monitoring; Quantitative analysis
• ISSN: 0007-4861; 1432-0800
• DOI: 10.1007/BF00197970

In Japan, the blood levels of chlordanes were determined by gas chromatography in termite-control workers who had used Chlordane, which was banned in 1986. The blood samples were obtained at annual physical examinations over the period 1987 90. In 1987, chlordanes were detected in most workers. trans-Nonachlor was detected at a peak level of 4.5 ppb, but little cis- or trans-chlordane was detected. A strong positive correlation was found for the observed total-chlordane concentration and the number of years of work. Overall, chlordane concentrations in blood tended to decrease over time, but the decrease was slower in the longer-exposed workers. Over time, trans-nonachlor, oxychlordane, and heptachlorepoxide were detected at higher levels than other chlordanes.