Circulating microRNAs as the Potential Diagnostic and Prognostic Biomarkers for Nasopharyngeal Carcinoma

Circulating microRNAs as the Potential Diagnostic and Prognostic Biomarkers for Nasopharyngeal Carcinoma

microRNAs are endogenous non-coding miRNAs, 19–25 nucleotides in length, that can be detected in the extracellular environment in stable forms, named circulating miRNAs (CIR-miRNAs). Since the first discovery of CIR-miRNAs, a large number of studies have demonstrated that the abnormal changes in its...

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Bibliographic Details
Published in:Genes Vol. 13; no. 7; p. 1160
Main Authors: Le, Thuy Ai Huyen, Lao, Thuan Duc
Format: Journal Article
Language:English
Published: Basel MDPI AG 27-06-2022
MDPI
Subjects:
Apoptosis
Autophagy
Biomarkers
Body fluids
Cancer
Epstein-Barr virus
Genes
Lymphoma
Medical diagnosis
Medical prognosis
MicroRNAs
miRNA
Nasopharyngeal carcinoma
Nucleotides
Proteins
Review
Tumorigenesis
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Summary:microRNAs are endogenous non-coding miRNAs, 19–25 nucleotides in length, that can be detected in the extracellular environment in stable forms, named circulating miRNAs (CIR-miRNAs). Since the first discovery of CIR-miRNAs, a large number of studies have demonstrated that the abnormal changes in its expression could be used to significantly distinguish nasopharyngeal carcinoma (NPC) from healthy cells. We herein reviewed and highlighted recent advances in the study of CIR-miRNAs in NPC, which pointed out the main components serving as promising and effective biomarkers for NPC diagnosis and prognosis. Furthermore, brief descriptions of its origin and unique characteristics are provided.
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ObjectType-Review-1
ISSN:2073-4425
2073-4425
DOI:10.3390/genes13071160