Post-extrasystolic left ventricular peak pressure with and without left ventricular failure

• Published in: Cardiovascular research Vol. 13; no. 6; p. 338
• Main Authors: Merillon, J P, Motte, G, Aumont, M C, Masquet, C, Lecarpentier, Y, Gourgon, R
• Format: Journal Article
• Language: English
• Published: England 01-06-1979
• Subjects: Adult; Aged; Aorta - physiopathology; Blood Pressure; Cardiac Complexes, Premature - physiopathology; Compliance; Female; Heart Failure - physiopathology; Heart Ventricles - physiopathology; Hemodynamics; Humans; Male; Middle Aged; Myocardial Contraction
• ISSN: 0008-6363
• DOI: 10.1093/cvr/13.6.338

18 patients without valvular pathology, coronary artery disease, or idiopathic hypertrophic subaortic stenosis were haemodynamically and angiographically investigated in order to analyse the effects of a ventricular extrasystolic beat upon the post-extrasystolic left ventricular peak pressure. In eight normal patients (group I), the post-extrasystolic peak pressure (P.ES.P.P.) was lower than that of the pre-extrasystolic beat; in 10 patients with symptoms of left ventricular failure (group II) the P.ES.P.P. significantly increased. The reasons are: 1) cardiac origin: stroke volume increased more in group II; 2) arterial origin. a) aortic compliance was lower in group II (this is probably related to the older age of patients in group II), and by decrease in end-diastolic aortic pressure was smaller in group II. Part of this arterial effect (2b) may probably be explained from the fact that post-extrasystolic compensatory pauses are equal in both groups, but the decay time of arterial pressure during diastole (assuming an exponential decay) is larger in group II. At the same age and with the identical aortic compliance only the two factors 1 and 2b play a part in the changes in P.ES.P.P.