Regulation of LRP-1 expression: Make the point

• Published in: Pathologie biologie (Paris) Vol. 62; no. 2; pp. 84 - 90
• Main Authors: Emonard, H., Théret, L., Bennasroune, A.H., Dedieu, S.
• Format: Journal Article
• Language: English
• Published: Paris Elsevier SAS 01-04-2014; Elsevier
• Subjects: Animals; Biological and medical sciences; Cell Membrane - metabolism; Cell receptors; Cell structures and functions; Cellular Microenvironment; Disease Progression; Endocytose; Endocytosis; Endocytosis - physiology; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Ligands; Low Density Lipoprotein Receptor-Related Protein-1 - biosynthesis; Low Density Lipoprotein Receptor-Related Protein-1 - chemistry; Low Density Lipoprotein Receptor-Related Protein-1 - genetics; Low Density Lipoprotein Receptor-Related Protein-1 - physiology; LRP-1; Mice; Miscellaneous; Models, Molecular; Molecular and cellular biology; Neoplasm Proteins - physiology; Neoplasms - pathology; Peptide Hydrolases - metabolism; Phosphorylation; Protein Conformation; Protein Folding; Protein Processing, Post-Translational; Protein Transport; Protéolyse; Shedding; Signal Transduction - physiology; Signaling; Signalisation; Structure-Activity Relationship; Signaling; Shedding; Endocytosis; Signalisation; Protéolyse; LRP-1; Endocytose; Signal transduction; Regulation(control); Proteolysis; Low density lipoprotein receptor-related protein 1; Gene expression; Biological receptor
• ISSN: 0369-8114; 1768-3114
• DOI: 10.1016/j.patbio.2014.02.002

The low-density lipoprotein receptor-related protein-1 (LRP-1) is a membrane receptor displaying both scavenging and signaling functions. The wide variety of extracellular ligands and of cytoplasmic scaffolding and signaling proteins interacting with LRP-1 gives it a major role not only in physiological processes, such as embryogenesis and development, but also in critical pathological situations, including cancer and neurological disorders. In this review, we describe the molecular mechanisms involved at distinct levels in the regulation of LRP-1, from its expression to the proper location and stability at the cell surface.
LRP-1 (low-density lipoprotein receptor-related protein-1) est un récepteur membranaire multifonctionnel portant à la fois des propriétés d’endocytose et de signalisation cellulaire. La grande variété de ligands extracellulaires et des protéines cytoplasmiques d’architecture et de signalisation capables d’interagir avec LRP-1 lui confère des rôles majeurs non seulement lors de processus physiologiques tels que l’embryogenèse et le développement, mais aussi lors de situations pathologiques critiques comme les pathologies tumorales ou neurodégénératives. Dans cette revue, nous décrivons les mécanismes moléculaires impliqués à différents niveaux dans le contrôle de la régulation de LRP-1, de son expression à sa localisation et sa stabilité à la surface cellulaire.