Infusion of the metabotropic receptor agonist, DCG-IV, into the main olfactory bulb induces olfactory preference learning in rat pups

• Published in: Brain research. Developmental brain research Vol. 128; no. 2; pp. 177 - 179
• Main Authors: Rumsey, Julie D, Darby-King, Andrea, Harley, Carolyn W, McLean, John H
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 29-06-2001
• Subjects: Animals; Animals, Newborn; Anticonvulsants - pharmacology; Conditioning (Psychology) - drug effects; Conditioning (Psychology) - physiology; Cyclopropanes - pharmacology; Dendrodendritic inhibition; Discrimination Learning - drug effects; Disinhibition; GABA; gamma-Aminobutyric Acid - physiology; Glycine - analogs & derivatives; Glycine - pharmacology; Granule cell; Inverted-U curve; Memory - drug effects; Memory - physiology; Memory formation; Mentha piperita; Microinjections; Mitral cell; Neonate; Neural Inhibition - drug effects; Neural Inhibition - physiology; NMDA; Odorants; Olfactory Bulb - cytology; Olfactory Bulb - drug effects; Olfactory Bulb - physiology; Olfactory Receptor Neurons - drug effects; Olfactory Receptor Neurons - physiology; Plant Extracts; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate - agonists; Receptors, Metabotropic Glutamate - physiology; Smell - physiology; Disinhibition; Granule cell; Neonate; Inverted-U curve; Mitral cell; Sensory systems; GABA; NMDA; Dendrodendritic inhibition; Memory formation
• ISSN: 0165-3806
• DOI: 10.1016/S0165-3806(01)00156-0

DCG-IV, a type 2 metabotropic glutamate receptor (mGluR2) agonist, was infused into the main olfactory bulb of 1-week-old pups exposed to peppermint odor. A preference for peppermint was demonstrated 24 h later. The data support the proposal that disinhibition at dendrodendritic synapses between granule cells and mitral cells is a critical component of olfactory memory formation in the rat pup olfactory bulb as well as in the accessory olfactory bulb of adult rodents.