Urokinase increases the content and activity of matrix metalloproteinases 2 and 9 during in vivo constrictive arterial remodeling

• Published in: Bulletin of experimental biology and medicine Vol. 139; no. 3; pp. 283 - 286
• Main Authors: Solomatina, M A, Plekhanova, O S, Men'shikova, M Yu, Ratner, E I, Tkachuk, V A, Parfenova, E V
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01-03-2005
• Subjects: Angioplasty, Balloon - adverse effects; Animals; Carotid Artery Injuries - pathology; Carotid Artery Injuries - physiopathology; Carotid Stenosis - enzymology; Carotid Stenosis - metabolism; Carotid Stenosis - pathology; Cell Count; Cell Proliferation; Constriction, Pathologic - drug therapy; Enzyme Activation - drug effects; Immunohistochemistry; Male; Matrix Metalloproteinase 2 - biosynthesis; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - biosynthesis; Matrix Metalloproteinase 9 - metabolism; Muscle, Smooth, Vascular - physiopathology; Rats; Rats, Wistar; Time Factors; Tunica Intima - drug effects; Tunica Intima - enzymology; Tunica Intima - pathology; Tunica Intima - physiopathology; Urokinase-Type Plasminogen Activator - pharmacology
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-005-0272-8

Perivascular application of urokinase to ballooned artery stimulating the formation of neointima and constrictive arterial remodeling increased the content and activity of matrix metalloproteinases 2 and 9 in vivo. Application of recombinant tissue plasminogen produced no such changes. It was demonstrated that urokinase stimulates expression of matrix metalloproteinases in vivo.