MHC-based diagnostics and therapeutics – clinical applications for disease-linked genes

• Published in: Immunology today Vol. 20; no. 4; pp. 161 - 165
• Main Authors: Howard, Maureen C, Spack, Edward G, Choudhury, Kalidip, Greten, Tim F, Schneck, Jonathan P
• Format: Journal Article Conference Proceeding
• Language: English
• Published: England Elsevier B.V 01-04-1999
• Subjects: AIDS/HIV; Animals; Autoimmune disease; Autoimmune Diseases - therapy; Gene Products, gag - metabolism; Gene Products, tax - metabolism; Gene-linkage; Histocompatibility Antigens - therapeutic use; HLA-A2 Antigen; Human T-lymphotropic virus 1; Humans; Immunoglobulin G - metabolism; Immunotherapeutics; Immunotherapy - trends; Major histocompatibility complex; Major Histocompatibility Complex - immunology; MHC; Mice; Paraparesis, Tropical Spastic - diagnosis; Paraparesis, Tropical Spastic - virology; T-Lymphocytes - immunology; Biotechnology; Immunotherapeutics; Immunology; Major histocompatibility complex; MHC; Autoimmune disease; Gene-linkage
• ISSN: 0167-5699
• DOI: 10.1016/S0167-5699(98)01390-5

Human diseases frequently occur in discrete, genetically susceptible groups rather than being distributed randomly in the population. As discussed at a recent symposium
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The symposium ‘MHC-based Therapeutics in Immunological Disorders’ was part of The American Association of Immunologists Meeting and was held in San Francisco, CA, USA, on 21 April 1998.
one set of well-known disease-linked genes, the major histocompatibility complex, are leading the way into the clinic.