Prevention of intrahepatic distant recurrence by transcatheter arterial infusion chemotherapy with platinum agents for stage I/II hepatocellular carcinoma

BACKGROUND: The effectiveness of additional chemotherapy in preventing intrahepatic distant tumor recurrence of hepatocellular carcinoma (HCC) has not been fully established. The authors compared the efficacy of 2 platinum‐based chemotherapeutic agents in combination with radical local treatment for...

Full description

Saved in:
Bibliographic Details
Published in:Cancer Vol. 117; no. 17; pp. 4018 - 4025
Main Authors: Ishikawa, Toru, Higuchi, Kazuo, Kubota, Tomoyuki, Seki, Keiichi, Honma, Terasu, Yoshida, Toshiaki, Kamimura, Tomoteru
Format: Journal Article
Language:English
Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-09-2011
Wiley Subscription Services, Inc
Subjects:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND: The effectiveness of additional chemotherapy in preventing intrahepatic distant tumor recurrence of hepatocellular carcinoma (HCC) has not been fully established. The authors compared the efficacy of 2 platinum‐based chemotherapeutic agents in combination with radical local treatment for preventing intrahepatic distant recurrence (IDR). METHODS: Seventy‐eight patients with stage I/II HCC aged 45 to 85 years underwent transcatheter arterial chemoembolization and/or radiofrequency ablation after they received hepatic arterial infusion (HAI) of platinum compounds. The HAI consisted of cis‐diammine(1,1‐cyclobutanedicarboxylato)platinum(II) (carboplatin) in 25 patients and cis‐diamminedichloroplatinum (II) (cisplatin) in 53 patients. Multivariate analysis was used to identify independent factors that were associated with IDR. RESULTS: Cumulative IDR rates at 1 year, 2 years, and 3 years were 21.7%, 52.2% and 75.7%, respectively, in the carboplatin group and 8.1%, 22.7%, and 36.9%, respectively, in the cisplatin group. The cisplatin group had a significantly lower IDR rate compared with the carboplatin group. The selection of a platinum agent was 1 of the independent factors for IDR in a multivariate Cox proportional hazards model. CONCLUSIONS: HAI chemotherapy with cisplatin before radical local treatment was effective in patients with HCC. The authors concluded that radical local treatment with concurrent HAI using cisplatin may contribute to a longer progression‐free period, which could be predicted with intrahepatic imaging in patients with stage I/II HCC. Cancer 2011;. © 2011 American Cancer Society. The authors compared the efficacy of 2 platinum‐based chemotherapeutic agents in combination with radical local treatment for preventing intrahepatic distant recurrence in patients with hepatocellular carcinoma (HCC). Hepatic arterial infusion (HAI) chemotherapy with cis‐diamminedichloroplatinum (II) (cisplatin) before radical local treatment was effective in patients with HCC. The results indicated that radical local treatment with concurrent HAI using cisplatin may contribute to a longer progression‐free period, which could be predicted with intrahepatic imaging in patients with stage I/II HCC.
Bibliography:Fax: (011) 81‐25‐233‐8880
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.25989