Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans

• Published in: Human molecular genetics Vol. 16; no. 15; pp. 1821 - 1827
• Main Authors: Koch, Werner, Hoppmann, Petra, Michou, Elena, Jung, Vanessa, Pfeufer, Arne, Mueller, Jakob C., Gieger, Christian, Wichmann, H.-Erich, Meitinger, Thomas, Schömig, Albert, Kastrati, Adnan
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01-08-2007; Oxford Publishing Limited (England)
• Subjects: Aged; Biological and medical sciences; Cardiology. Vascular system; Case-Control Studies; Coronary heart disease; DEAD-box RNA Helicases - genetics; European Continental Ancestry Group - genetics; Female; Fundamental and applied biological sciences. Psychology; Galectin 2 - genetics; Genetic Predisposition to Disease; Genetics of eukaryotes. Biological and molecular evolution; Genome, Human; Genotype; Haplotypes; Heart; Histocompatibility Antigens Class II - genetics; Humans; Lymphotoxin-alpha - genetics; Male; Medical sciences; Middle Aged; Molecular and cellular biology; Myocardial Infarction - ethnology; Myocardial Infarction - genetics; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Europe; Myocardial infarction; Variant; Association; Heart disease; Genomics; Cardiovascular disease; Genetics; European; Myocardial disease; Protection
• ISSN: 0964-6906; 1460-2083
• DOI: 10.1093/hmg/ddm130

Single-nucleotide polymorphisms within the BAT1-NFKBIL1-LTA genomic region (6p21.3) and the LGALS2 gene (22q13.1), encoding a regulator for lymphotoxin-α, the product of the LTA gene, have been reported to be linked with the risk of myocardial infarction in Japanese. We employed nine polymorphisms from the BAT1-NFKBIL1-LTA region and one polymorphism from the LGALS2 gene, and investigated whether such associations were also present in Europeans. The study included 3657 patients with myocardial infarction and 1211 control individuals with angiographically normal coronary arteries. Minor homozygous genotypes of polymorphisms in BAT1 (rs2239527, −23C/G), NFKBIL1 (rs2071592, −63T/A) and LTA (rs1800683, −162G/A; rs909253, 252G/A; rs1041981, Thr26Asn) were associated with moderately protective effects against myocardial infarction (P ≤ 0.045). The most abundant 9-marker haplotype of the BAT1-NFKBIL1-LTA region, named haplotype 1 (28% frequency in the study population), included the alleles of the five protective genotypes and was related with a significantly lower risk of myocardial infarction (OR 0.88, 95% CI 0.80–0.98; P = 0.015). Moreover, homozygosity for haplotype 1 was associated with an OR 0.72 (95% CI 0.57–0.90; P = 0.0047). Multiple logistic regression analysis revealed an independent protective effect against myocardial infarction in the homozygous carriers of haplotype 1 (adjusted OR 0.78, 95% CI 0.62–0.99; P = 0.043). A putative risk genotype of the polymorphism in the LGALS2 gene (rs7291467; 3279T/C) was not associated with myocardial infarction (OR 0.98, 95% CI 0.83–1.16; P = 0.84). Our finding that protective effects are linked with minor homozygous genotypes and haplotype 1 of the BAT1-NFKBIL1-LTA region in Europeans is opposite to the observation of associated risks in Japanese.