New anti-Malarial compounds from database searching

• Published in: Bioorganic & medicinal chemistry letters Vol. 12; no. 4; pp. 539 - 542
• Main Authors: Griffith, Renate, Chanphen, Rachada, Leach, Scott P, Keller, Paul A
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 25-02-2002; Elsevier
• Subjects: Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimalarials - chemistry; Antimalarials - pharmacology; Antiparasitic agents; Biological and medical sciences; Databases, Factual; Heterocyclic Compounds; HIV Reverse Transcriptase - antagonists & inhibitors; Humans; Inhibitory Concentration 50; Medical sciences; Pharmacology. Drug treatments; Plasmodium falciparum - drug effects; Reverse Transcriptase Inhibitors - pharmacology; Structure-Activity Relationship; Protozoa; Antimalarial; Apicomplexa; Aminoalcohol; Isoquinoline derivatives; Nitrogen heterocycle; Coumarine derivatives; Quinone; Ketol; Tricyclic compound; Oxygen heterocycle; Screening test; In vitro; Screening; Plasmodium falciparum; Synthetic product; Cinnamic acid derivatives; Parasiticid; Database; Pyrimidine derivatives; Aromatic compound; Quinonemethide; Oxygen nitrogen heterocycle
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/S0960-894X(01)00811-3

In a serendipitous result, pharmacophores generated for the database searching for new non-nucleoside inhibitors of the HIV-1 reverse transcriptase enzyme unearthed 12 new lead compounds which were active against the
Plasmodium falciparum strain of malaria.
The structure and activity of new anti-malarial compounds from database searching are reported.