Growth hormone therapy for adult growth hormone deficiency
GH deficiency in adult life is associated with a number of adverse biological changes including osteopenia, reduced exercise capacity, altered body composition, deleterious alterations in the lipid profile and insulin status, and reduced quality of life. Potentially, most of these changes can be rev...
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| Published in: | Trends in Endocrinology & Metabolism Vol. 7; no. 8; pp. 287 - 290 |
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| Main Authors: | , , |
| Format: | Book Review Journal Article |
| Language: | English |
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London
Elsevier Ltd
01-10-1996
Elsevier |
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| Abstract | GH deficiency in adult life is associated with a number of adverse biological changes including osteopenia, reduced exercise capacity, altered body composition, deleterious alterations in the lipid profile and insulin status, and reduced quality of life. Potentially, most of these changes can be reversed by GH replacement therapy. In an era of health rationing, however, GH replacement is unlikely to be offered to every GH-deficient adult. Therefore, we have proposed a strategy aimed at delineating which adults with GH deficiency might benefit most from GH therapy. |
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| AbstractList | GH deficiency in adult life is associated with a number of adverse biological changes including osteopenia, reduced exercise capacity, altered body composition, deleterious alterations in the lipid profile and insulin status, and reduced quality of life. Potentially, most of these changes can be reversed by GH replacement therapy. In an era of health rationing, however, GH replacement is unlikely to be offered to every GH-deficient adult. Therefore, we have proposed a strategy aimed at delineating which adults with GH deficiency might benefit most from GH therapy. |
| Author | Shalet, Stephen M. Toogood, Andrew A. Rahim, Asad |
| Author_xml | – sequence: 1 givenname: Stephen M. surname: Shalet fullname: Shalet, Stephen M. – sequence: 2 givenname: Asad surname: Rahim fullname: Rahim, Asad – sequence: 3 givenname: Andrew A. surname: Toogood fullname: Toogood, Andrew A. |
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| Cites_doi | 10.1016/0140-6736(90)91812-O 10.1046/j.1365-2265.1996.671492.x 10.1111/j.1365-2265.1994.tb02583.x 10.1111/j.1651-2227.1989.tb11242.x 10.1210/er.16.1.63 10.1210/jc.78.3.669 10.1159/000126813 10.1210/jc.81.8.2865 10.1016/0026-0495(93)90145-E 10.1016/S0140-6736(89)92328-3 10.1111/j.1365-2265.1995.tb01908.x 10.1111/j.1365-2265.1995.tb02688.x 10.1111/j.1365-2265.1994.tb02452.x 10.1210/jc.80.2.552 10.1111/j.1365-2265.1995.tb00536.x 10.1111/j.1365-2265.1995.tb01909.x 10.1056/NEJM198912283212605 10.1016/0140-6736(92)92892-J 10.1210/jc.76.5.1344 10.1016/0026-0495(94)90245-3 10.1016/0140-6736(93)92664-F 10.1111/j.1365-2265.1995.tb02690.x 10.2165/00019053-199406050-00005 10.1042/cs0890321 10.1161/01.ATV.13.2.296 |
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| Copyright | 1996 1996 INIST-CNRS |
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| Keywords | Endocrinopathy Human Chemotherapy Replacement therapy Adenohypophyseal hormone Deficiency STH Adult Review |
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| References | Beshyah, Gelding, Andres, Johnston (BIB2) 1995; 89 Holmes, Shalet (BIB12) 1995; 43 Johansson, Larson, Andersson (BIB16) 1995; 61 Salomon, Cuneo, Hesp, Sönksen (BIB29) 1989; 321 Eden, Wiklund, Oscarsson, Rosén, Bengtsson (BIB7) 1993; 13 Holmes, Shalet (BIB10) 1995; 43 De-Boer, Blok, Voerman, Phillips, Schouten (BIB5) 1994; 43 Nicolson, Toogood, Rahim, Shalet (BIB23) 1996; 44 Cuneo, Salomon, Watts, Hesp, Sonksen (BIB4) 1993; 42 Rosen, Bengtsson (BIB25) 1990; 336 Beshyah, Henderson, Niththyanathan, Sharp, Richmond, Johnston (BIB1) 1994; 1 Holmes, Whitehouse, Swindell, Economou, Adams, Shalet (BIB14) 1995; 42 O'Halloran, Tsatsoulis, Whitehouse, Holmes, Adams, Shalet (BIB24) 1993; 76 Rosen, Wilhelmsen, Landin-Wilhelmsen, Lappas, Lindstedt, Bengtsson (BIB28) 1995 Jorgensen, Pedersen, Thuesen (BIB17) 1989; 1 Hansen, Vahl, Jorgensen, Christiansen, Hagen (BIB9) 1995; 43 Rosén, Johannsson, Hallgren, Caidahl, Bosaeus, Bengtsson (BIB26) 1994; 1 Erfurth, Bülow, Mikozy, Nordström, Hagmar (BIB8) 1996; 3 De-Boer, Blok, van-der-Veen (BIB6) 1995; 16 Holmes, Shalet (BIB11) 1995; 42 Johannsson, Rosén, Bosaeus, Sjostrom, Bengtsson (BIB15) 1996 McKenna, Doward (BIB21) 1994; 6 Mårdh, Lundin, Borg, Jonsson, Lindeberg (BIB19) 1994; 1 Holmes, Economou, Whitehouse, Adams, Shalet (BIB13) 1994; 78 Rosén, Wiren, Wilhelmsen, Wiklund, Bengtsson (BIB27) 1994; 40 Björk, Jönsson, Westphal, Levin (BIB3) 1989; 356 Lehmann, Hopkins, Weissberger, Gosling, Sönksen (BIB18) 1993; 341 Markussis, Beshyah, Fisher, Sharp, Nicolaides, Johnston (BIB20) 1992; 340 Nass, Huber, Klauss, Müller, Schopohl, Strasburger (BIB22) 1995; 80 Toogood, Beardwell, Shalet (BIB30) 1994; 41 Holmes (10.1016/S1043-2760(96)00130-0_BIB12) 1995; 43 Mårdh (10.1016/S1043-2760(96)00130-0_BIB19) 1994; 1 De-Boer (10.1016/S1043-2760(96)00130-0_BIB5) 1994; 43 Jorgensen (10.1016/S1043-2760(96)00130-0_BIB17) 1989; 1 Rosén (10.1016/S1043-2760(96)00130-0_BIB26) 1994; 1 De-Boer (10.1016/S1043-2760(96)00130-0_BIB6) 1995; 16 Björk (10.1016/S1043-2760(96)00130-0_BIB3) 1989; 356 Holmes (10.1016/S1043-2760(96)00130-0_BIB14) 1995; 42 Markussis (10.1016/S1043-2760(96)00130-0_BIB20) 1992; 340 Johansson (10.1016/S1043-2760(96)00130-0_BIB16) 1995; 61 Lehmann (10.1016/S1043-2760(96)00130-0_BIB18) 1993; 341 Holmes (10.1016/S1043-2760(96)00130-0_BIB10) 1995; 43 Cuneo (10.1016/S1043-2760(96)00130-0_BIB4) 1993; 42 Erfurth (10.1016/S1043-2760(96)00130-0_BIB8) 1996; 3 Beshyah (10.1016/S1043-2760(96)00130-0_BIB1) 1994; 1 Holmes (10.1016/S1043-2760(96)00130-0_BIB13) 1994; 78 Salomon (10.1016/S1043-2760(96)00130-0_BIB29) 1989; 321 Hansen (10.1016/S1043-2760(96)00130-0_BIB9) 1995; 43 Toogood (10.1016/S1043-2760(96)00130-0_BIB30) 1994; 41 Holmes (10.1016/S1043-2760(96)00130-0_BIB11) 1995; 42 Eden (10.1016/S1043-2760(96)00130-0_BIB7) 1993; 13 Rosen (10.1016/S1043-2760(96)00130-0_BIB28) 1995 Johannsson (10.1016/S1043-2760(96)00130-0_BIB15) 1996 Beshyah (10.1016/S1043-2760(96)00130-0_BIB2) 1995; 89 Nass (10.1016/S1043-2760(96)00130-0_BIB22) 1995; 80 O'Halloran (10.1016/S1043-2760(96)00130-0_BIB24) 1993; 76 Rosén (10.1016/S1043-2760(96)00130-0_BIB27) 1994; 40 Rosen (10.1016/S1043-2760(96)00130-0_BIB25) 1990; 336 McKenna (10.1016/S1043-2760(96)00130-0_BIB21) 1994; 6 Nicolson (10.1016/S1043-2760(96)00130-0_BIB23) 1996; 44 |
| References_xml | – volume: 336 start-page: 285 year: 1990 end-page: 288 ident: BIB25 article-title: Premature mortality due to cardiovascular disease in hypopituitarism publication-title: Lancet contributor: fullname: Bengtsson – volume: 1 start-page: 55 year: 1994 end-page: 66 ident: BIB26 article-title: Beneficial effects of 12 months replacement with recombinant human growth hormone to growth hormone deficient adults publication-title: Endocrinol Metabol contributor: fullname: Bengtsson – volume: 40 start-page: 111 year: 1994 end-page: 116 ident: BIB27 article-title: Decreased psychological well-being in adult patients with growth hormone deficiency publication-title: Clin Endocrinol (Oxf) contributor: fullname: Bengtsson – volume: 341 start-page: 309 year: 1993 ident: BIB18 article-title: Aortic distensibility in growth hormone deficient adults publication-title: Lancet contributor: fullname: Sönksen – volume: 89 start-page: 321 year: 1995 end-page: 328 ident: BIB2 article-title: β-Cell function in hypopituitary adults before and during growth hormone treatment publication-title: Clin Sci contributor: fullname: Johnston – volume: 3 start-page: 121 year: 1996 ident: BIB8 article-title: Increased cardiovascular mortality in patients with hypopituitarism publication-title: Proceedings of the 20th International Symposium: growth hormone and growth factors in endocrinology and metabolism, Berlin contributor: fullname: Hagmar – volume: 42 start-page: 613 year: 1995 end-page: 618 ident: BIB11 article-title: Characteristics of adults who wish to enter a trial of growth hormone replacement publication-title: Clin Endocrinol (Oxf) contributor: fullname: Shalet – volume: 43 start-page: 143 year: 1995 end-page: 149 ident: BIB10 article-title: Which adults develop side-effects of growth hormone replacement publication-title: Clin Endocrinol (Oxf) contributor: fullname: Shalet – volume: 44 start-page: 311 year: 1996 end-page: 316 ident: BIB23 article-title: The prevalence of severe growth hormone deficiency in adults who received growth hormone replacement in childhood publication-title: Clin Endocrinol (Oxf) contributor: fullname: Shalet – volume: 16 start-page: 63 year: 1995 end-page: 86 ident: BIB6 article-title: Clinical aspects of growth hormone deficiency in adults publication-title: Endocr Rev contributor: fullname: van-der-Veen – start-page: 2 year: 1995 ident: BIB28 article-title: Increased fracture rate in growth hormone deficient adults publication-title: Proceedings of the 77th Annual Meeting of the Endocrine Society contributor: fullname: Bengtsson – volume: 43 start-page: 199 year: 1994 end-page: 203 ident: BIB5 article-title: Serum lipid levels in growth hormone deficient men publication-title: Metabolism contributor: fullname: Schouten – volume: 43 start-page: 151 year: 1995 end-page: 157 ident: BIB12 article-title: Factors influencing the desire for long term growth hormone replacement in adults publication-title: Clin Endocrinol (Oxf) contributor: fullname: Shalet – volume: 80 start-page: 552 year: 1995 end-page: 557 ident: BIB22 article-title: Effect of growth hormone replacement therapy on physical work capacity and cardiac and pulmonary function in patients with hGH deficiency acquired in adulthood publication-title: J Clin Endocrinol Metabol contributor: fullname: Strasburger – volume: 41 start-page: 511 year: 1994 end-page: 516 ident: BIB30 article-title: The severity of growth hormone deficiency in adults with pituitary disease is related to the degree of hypopituitarism publication-title: Clin Endocrinol (Oxf) contributor: fullname: Shalet – volume: 1 start-page: 43 year: 1994 end-page: 49 ident: BIB19 article-title: Growth hormone replacement therapy in adult hypopituitary patients with growth hormone deficiency: combined data from 12 European placebo-controlled clinical trials publication-title: Endocrinol Metabol contributor: fullname: Lindeberg – volume: 42 start-page: 627 year: 1995 end-page: 633 ident: BIB14 article-title: Effect of growth hormone replacement on bone mass in adults with adult onset growth hormone deficiency publication-title: Clin Endocrinol (Oxf) contributor: fullname: Shalet – volume: 61 start-page: 57 year: 1995 end-page: 66 ident: BIB16 article-title: Treatment of growth hormone deficient adults with recombinant human growth hormone increases the concentration of growth hormone in the cerebrospinal fluid and affects neurotransmitters publication-title: Neuroendocrinology contributor: fullname: Andersson – volume: 13 start-page: 296 year: 1993 end-page: 301 ident: BIB7 article-title: Growth hormone treatment of growth hormone deficient adults results in a marked increase in Lp(a) and HDL cholesterol concentrations publication-title: Arteriosclerosis Thrombosis contributor: fullname: Bengtsson – year: 1996 ident: BIB15 article-title: Long-term growth hormone treatment increases bone mineral content and density in patients with adult-onset growth hormone deficiency publication-title: J Clin Endocrinol Metabol contributor: fullname: Bengtsson – volume: 321 start-page: 1797 year: 1989 end-page: 1803 ident: BIB29 article-title: The effects of treatment with recombinant human growth hormone on body composition in adults with growth hormone deficiency publication-title: N Engl J Med contributor: fullname: Sönksen – volume: 42 start-page: 1519 year: 1993 end-page: 1523 ident: BIB4 article-title: Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency publication-title: Metabolism contributor: fullname: Sonksen – volume: 356 start-page: 55 year: 1989 end-page: 59 ident: BIB3 article-title: Quality of life of adults with growth hormone deficiency: a controlled study publication-title: Acta Paediatr Scand contributor: fullname: Levin – volume: 1 start-page: 173 year: 1994 end-page: 180 ident: BIB1 article-title: Metabolic abnormalities in growth hormone deficient adults: carbohydrate tolerance and lipid metabolism publication-title: Endocrinol Metabol contributor: fullname: Johnston – volume: 43 start-page: 689 year: 1995 end-page: 696 ident: BIB9 article-title: Whole body and regional soft tissue changes in growth hormone deficient adults after one year of growth hormone treatment: a double-blind, randomised, placebo-controlled study publication-title: Clin Endocrinol (Oxf) contributor: fullname: Hagen – volume: 76 start-page: 1344 year: 1993 end-page: 1348 ident: BIB24 article-title: Increased bone density after recombinant human growth hormone therapy in adults with isolated GH deficiency publication-title: J Clin Endocrinol Metabol contributor: fullname: Shalet – volume: 78 start-page: 669 year: 1994 end-page: 674 ident: BIB13 article-title: Reduced bone mineral density in patients with adult onset growth hormone deficiency publication-title: J Clin Endocrinol Metabol contributor: fullname: Shalet – volume: 1 start-page: 1221 year: 1989 end-page: 1225 ident: BIB17 article-title: Beneficial effects of growth hormone treatment in GH-deficient adults publication-title: Lancet contributor: fullname: Thuesen – volume: 6 start-page: 434 year: 1994 end-page: 441 ident: BIB21 article-title: Quality of life assessment of adults with growth hormone deficiency. Implications for drug therapy publication-title: Pharmaco-Economics contributor: fullname: Doward – volume: 340 start-page: 1188 year: 1992 end-page: 1192 ident: BIB20 article-title: Detection of premature atherosclerosis by high resolution ultrasonography in symptom-free hypopituitary adults publication-title: Lancet contributor: fullname: Johnston – volume: 336 start-page: 285 year: 1990 ident: 10.1016/S1043-2760(96)00130-0_BIB25 article-title: Premature mortality due to cardiovascular disease in hypopituitarism publication-title: Lancet doi: 10.1016/0140-6736(90)91812-O contributor: fullname: Rosen – volume: 44 start-page: 311 year: 1996 ident: 10.1016/S1043-2760(96)00130-0_BIB23 article-title: The prevalence of severe growth hormone deficiency in adults who received growth hormone replacement in childhood publication-title: Clin Endocrinol (Oxf) doi: 10.1046/j.1365-2265.1996.671492.x contributor: fullname: Nicolson – volume: 41 start-page: 511 year: 1994 ident: 10.1016/S1043-2760(96)00130-0_BIB30 article-title: The severity of growth hormone deficiency in adults with pituitary disease is related to the degree of hypopituitarism publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.1994.tb02583.x contributor: fullname: Toogood – volume: 356 start-page: 55 year: 1989 ident: 10.1016/S1043-2760(96)00130-0_BIB3 article-title: Quality of life of adults with growth hormone deficiency: a controlled study publication-title: Acta Paediatr Scand doi: 10.1111/j.1651-2227.1989.tb11242.x contributor: fullname: Björk – volume: 16 start-page: 63 year: 1995 ident: 10.1016/S1043-2760(96)00130-0_BIB6 article-title: Clinical aspects of growth hormone deficiency in adults publication-title: Endocr Rev doi: 10.1210/er.16.1.63 contributor: fullname: De-Boer – volume: 78 start-page: 669 year: 1994 ident: 10.1016/S1043-2760(96)00130-0_BIB13 article-title: Reduced bone mineral density in patients with adult onset growth hormone deficiency publication-title: J Clin Endocrinol Metabol doi: 10.1210/jc.78.3.669 contributor: fullname: Holmes – volume: 61 start-page: 57 year: 1995 ident: 10.1016/S1043-2760(96)00130-0_BIB16 article-title: Treatment of growth hormone deficient adults with recombinant human growth hormone increases the concentration of growth hormone in the cerebrospinal fluid and affects neurotransmitters publication-title: Neuroendocrinology doi: 10.1159/000126813 contributor: fullname: Johansson – year: 1996 ident: 10.1016/S1043-2760(96)00130-0_BIB15 article-title: Long-term growth hormone treatment increases bone mineral content and density in patients with adult-onset growth hormone deficiency publication-title: J Clin Endocrinol Metabol doi: 10.1210/jc.81.8.2865 contributor: fullname: Johannsson – volume: 42 start-page: 1519 year: 1993 ident: 10.1016/S1043-2760(96)00130-0_BIB4 article-title: Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency publication-title: Metabolism doi: 10.1016/0026-0495(93)90145-E contributor: fullname: Cuneo – volume: 1 start-page: 1221 year: 1989 ident: 10.1016/S1043-2760(96)00130-0_BIB17 article-title: Beneficial effects of growth hormone treatment in GH-deficient adults publication-title: Lancet doi: 10.1016/S0140-6736(89)92328-3 contributor: fullname: Jorgensen – volume: 43 start-page: 143 year: 1995 ident: 10.1016/S1043-2760(96)00130-0_BIB10 article-title: Which adults develop side-effects of growth hormone replacement publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.1995.tb01908.x contributor: fullname: Holmes – volume: 42 start-page: 613 year: 1995 ident: 10.1016/S1043-2760(96)00130-0_BIB11 article-title: Characteristics of adults who wish to enter a trial of growth hormone replacement publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.1995.tb02688.x contributor: fullname: Holmes – volume: 40 start-page: 111 year: 1994 ident: 10.1016/S1043-2760(96)00130-0_BIB27 article-title: Decreased psychological well-being in adult patients with growth hormone deficiency publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.1994.tb02452.x contributor: fullname: Rosén – volume: 80 start-page: 552 year: 1995 ident: 10.1016/S1043-2760(96)00130-0_BIB22 article-title: Effect of growth hormone replacement therapy on physical work capacity and cardiac and pulmonary function in patients with hGH deficiency acquired in adulthood publication-title: J Clin Endocrinol Metabol doi: 10.1210/jc.80.2.552 contributor: fullname: Nass – volume: 43 start-page: 689 year: 1995 ident: 10.1016/S1043-2760(96)00130-0_BIB9 article-title: Whole body and regional soft tissue changes in growth hormone deficient adults after one year of growth hormone treatment: a double-blind, randomised, placebo-controlled study publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.1995.tb00536.x contributor: fullname: Hansen – volume: 43 start-page: 151 year: 1995 ident: 10.1016/S1043-2760(96)00130-0_BIB12 article-title: Factors influencing the desire for long term growth hormone replacement in adults publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.1995.tb01909.x contributor: fullname: Holmes – volume: 321 start-page: 1797 year: 1989 ident: 10.1016/S1043-2760(96)00130-0_BIB29 article-title: The effects of treatment with recombinant human growth hormone on body composition in adults with growth hormone deficiency publication-title: N Engl J Med doi: 10.1056/NEJM198912283212605 contributor: fullname: Salomon – volume: 340 start-page: 1188 year: 1992 ident: 10.1016/S1043-2760(96)00130-0_BIB20 article-title: Detection of premature atherosclerosis by high resolution ultrasonography in symptom-free hypopituitary adults publication-title: Lancet doi: 10.1016/0140-6736(92)92892-J contributor: fullname: Markussis – volume: 76 start-page: 1344 year: 1993 ident: 10.1016/S1043-2760(96)00130-0_BIB24 article-title: Increased bone density after recombinant human growth hormone therapy in adults with isolated GH deficiency publication-title: J Clin Endocrinol Metabol doi: 10.1210/jc.76.5.1344 contributor: fullname: O'Halloran – volume: 43 start-page: 199 year: 1994 ident: 10.1016/S1043-2760(96)00130-0_BIB5 article-title: Serum lipid levels in growth hormone deficient men publication-title: Metabolism doi: 10.1016/0026-0495(94)90245-3 contributor: fullname: De-Boer – volume: 341 start-page: 309 year: 1993 ident: 10.1016/S1043-2760(96)00130-0_BIB18 article-title: Aortic distensibility in growth hormone deficient adults publication-title: Lancet doi: 10.1016/0140-6736(93)92664-F contributor: fullname: Lehmann – volume: 3 start-page: 121 year: 1996 ident: 10.1016/S1043-2760(96)00130-0_BIB8 article-title: Increased cardiovascular mortality in patients with hypopituitarism contributor: fullname: Erfurth – volume: 42 start-page: 627 year: 1995 ident: 10.1016/S1043-2760(96)00130-0_BIB14 article-title: Effect of growth hormone replacement on bone mass in adults with adult onset growth hormone deficiency publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.1995.tb02690.x contributor: fullname: Holmes – volume: 6 start-page: 434 year: 1994 ident: 10.1016/S1043-2760(96)00130-0_BIB21 article-title: Quality of life assessment of adults with growth hormone deficiency. Implications for drug therapy publication-title: Pharmaco-Economics doi: 10.2165/00019053-199406050-00005 contributor: fullname: McKenna – volume: 89 start-page: 321 year: 1995 ident: 10.1016/S1043-2760(96)00130-0_BIB2 article-title: β-Cell function in hypopituitary adults before and during growth hormone treatment publication-title: Clin Sci doi: 10.1042/cs0890321 contributor: fullname: Beshyah – volume: 13 start-page: 296 year: 1993 ident: 10.1016/S1043-2760(96)00130-0_BIB7 article-title: Growth hormone treatment of growth hormone deficient adults results in a marked increase in Lp(a) and HDL cholesterol concentrations publication-title: Arteriosclerosis Thrombosis doi: 10.1161/01.ATV.13.2.296 contributor: fullname: Eden – volume: 1 start-page: 173 year: 1994 ident: 10.1016/S1043-2760(96)00130-0_BIB1 article-title: Metabolic abnormalities in growth hormone deficient adults: carbohydrate tolerance and lipid metabolism publication-title: Endocrinol Metabol contributor: fullname: Beshyah – volume: 1 start-page: 43 issue: Suppl A year: 1994 ident: 10.1016/S1043-2760(96)00130-0_BIB19 article-title: Growth hormone replacement therapy in adult hypopituitary patients with growth hormone deficiency: combined data from 12 European placebo-controlled clinical trials publication-title: Endocrinol Metabol contributor: fullname: Mårdh – start-page: 2 year: 1995 ident: 10.1016/S1043-2760(96)00130-0_BIB28 article-title: Increased fracture rate in growth hormone deficient adults contributor: fullname: Rosen – volume: 1 start-page: 55 year: 1994 ident: 10.1016/S1043-2760(96)00130-0_BIB26 article-title: Beneficial effects of 12 months replacement with recombinant human growth hormone to growth hormone deficient adults publication-title: Endocrinol Metabol contributor: fullname: Rosén |
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| Title | Growth hormone therapy for adult growth hormone deficiency |
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