Hypoglycemic effect of lupin seed γ-conglutin in experimental animals and healthy human subjects

• Published in: Fitoterapia Vol. 82; no. 7; pp. 933 - 938
• Main Authors: Bertoglio, Juan C., Calvo, Mario A., Hancke, Juan L., Burgos, Rafael A., Riva, Antonella, Morazzoni, Paolo, Ponzone, Cesare, Magni, Chiara, Duranti, Marcello
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01-10-2011; Elsevier
• Subjects: Adult; Animal trial; Animals; Antidiabetic; Biological and medical sciences; Blood Glucose - metabolism; Dose-Response Relationship, Drug; Female; General pharmacology; Glucose Tolerance Test; Human study; Humans; Hypoglycemic Agents - pharmacology; Lupinus - chemistry; Lupinus albus; Male; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Proteins - pharmacology; Protein extract; Rats; Reference Values; Seeds; LDH; GGT; Antidiabetic; Lupinus albus; Protein extract; BUN; GPT; Animal trial; GOT; Human study; BMI; Human; Seeds; Healthy subject; Pharmacognosy; Extract; Protein; Medicinal plant; Hypoglycemic agent; Leguminosae; Dicotyledones; Animal; Angiospermae; Plant origin; Spermatophyta; Fodder crop
• ISSN: 0367-326X; 1873-6971
• DOI: 10.1016/j.fitote.2011.05.007

A lupin seed γ-conglutin-enriched preparation was tested in a glucose overload trial with both murine models and adult healthy volunteers. The results with rats showed a dose-dependent significant decrease of blood glucose concentration, which confirmed previous findings obtained with the purified protein. Moreover, three test-product doses equivalent to 630, 315, and 157.5mg γ-conglutin, orally administered 30min before the carbohydrate supply, showed a relevant hypoglycemic effect in human trials. Insulin concentrations were not significantly affected. The general hematic parameters did not change at all.
This is the first report on the glucose-lowering effect of lupin γ-conglutin in human subjects.
Decreasing effect of three doses of a lupin seed γ-conglutin-enriched preparation on plasma glucose in a human trial with 15 glucose-overloaded healthy subjects. [Display omitted]