Cycloartane saponins from Astragalus peregrinus as modulators of lymphocyte proliferation

From Astragalus peregrinus, four cycloartane-type saponins have been isolated and their structures elucidated by spectral means as 20( R),24( S)-epoxy-9β,19-cyclolanostane-3β,6α,16β,25-tetrol 3- O-β- d-glucopyranoside ( 1), 20( R),24( S)-epoxy-9β,19-cyclolanostane-3β,6α,16β,25-tetrol 3- O-α- l-rhamn...

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Bibliographic Details
Published in:	Fitoterapia Vol. 72; no. 8; pp. 894 - 905
Main Authors:	Verotta, Luisella, Guerrini, Marco, El-Sebakhy, N.A, Asaad, Aya M, Toaima, Soad M, Abou-Sheer, Moahamed E, Luo, Ying-De, Pezzuto, John M
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 01-12-2001 Elsevier
Subjects:	Adjuvants, Immunologic - pharmacology Adjuvants, Immunologic - therapeutic use Animals Astragalus peregrinus Biological and medical sciences Cycloastragenol glycosides Fabaceae Female General pharmacology Humans Lymphocyte proliferation modulators Lymphocytes - drug effects Medical sciences Mice Mice, Inbred Strains Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Structures Saponins Saponins - pharmacology Saponins - therapeutic use Spleen - cytology Spleen - drug effects Tumor Cells, Cultured - drug effects Cycloastragenol glycosides Saponins Astragalus peregrinus Lymphocyte proliferation modulators Human Cell proliferation Pharmacognosy Cytotoxicity In vitro Biological activity Medicinal plant Saponin Immunomodulator Leguminosae Dicotyledones Animal Angiospermae Plant origin Isolation Spermatophyta Lymphocyte Tumor cell Structural analysis
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Summary:	From Astragalus peregrinus, four cycloartane-type saponins have been isolated and their structures elucidated by spectral means as 20( R),24( S)-epoxy-9β,19-cyclolanostane-3β,6α,16β,25-tetrol 3- O-β- d-glucopyranoside ( 1), 20( R),24( S)-epoxy-9β,19-cyclolanostane-3β,6α,16β,25-tetrol 3- O-α- l-rhamnopyranosyl-(1→4)-β- d-glucopyranoside ( 2), 20( R),24( S)-epoxy-9β,19-cyclolanostane-3β,6α,16β,25-tetrol 3- O-α- l-rhamnopyranosyl-(1→2)-β- d-glucopyranoside ( 3) and 20( R),25-epoxy-9β,19-cyclolanostane-3β,6α,16β,24( S)-tetrol (24- O-acetyl)- 3- O-α- l-rhamnopyranosyl-(1→2)-(6′- O-acetyl)-β- d-glucopyranoside ( 4). Compounds 2 and 3 showed to stimulate the proliferation of mouse splenocytes and were not significantly cytotoxic.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0367-326X
DOI:	10.1016/S0367-326X(01)00339-2