Treatment of malnutrition with 1.1% amino acid peritoneal dialysis solution: Results of a multicenter outpatient study

• Published in: American journal of kidney diseases Vol. 32; no. 5; pp. 761 - 769
• Main Authors: Jones, M, Hagen, T, Boyle, CA, Vonesh, E, Hamburger, R, Charytan, C, Sandroni, S, Bernard, D, Piraino, B, Schreiber, M, Gehr, T, Fein, P, Friedlander, M, Burkart, J, Ross, D, Zimmerman, S, Swartz, R, Knight, T, Kraus, A, McDonald, L, Hartnett, M, Weaver, M, Martis, L, Moran, J
• Format: Journal Article
• Language: English
• Published: Orlando, FL Elsevier Inc 01-11-1998; Elsevier
• Subjects: Amino Acids - administration & dosage; Amino Acids - therapeutic use; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Arm - anatomy & histology; Biological and medical sciences; Blood Proteins - analysis; Dialysis Solutions - administration & dosage; Dialysis Solutions - therapeutic use; Emergency and intensive care: renal failure. Dialysis management; Female; Glucose - administration & dosage; Glucose - therapeutic use; Humans; Insulin-Like Growth Factor I - analysis; Intensive care medicine; Male; Medical sciences; Middle Aged; Muscle, Skeletal - anatomy & histology; Nutrition Disorders - therapy; Osmosis; Peritoneal Dialysis, Continuous Ambulatory - methods; Peritoneum - metabolism; Phosphates - blood; Potassium - blood; Prealbumin - analysis; Prospective Studies; Serum Albumin - analysis; Transferrin - analysis; Kidney disease; Human; Urinary system disease; Nutrition disorder; Dialysate; Peritoneal dialysis; Extrarenal dialysis; Chronic; Treatment; Aminoacid; Renal failure; Complication; Malnutrition
• ISSN: 0272-6386; 1523-6838
• DOI: 10.1016/S0272-6386(98)70131-3

A peritoneal dialysis (PD) solution containing 1.1% amino acids as the osmotic agent was evaluated in a 3-month randomized, prospective, open- label study in malnourished PD patients. Patients in the treatment group (DAA) received one or two exchanges daily with the amino acid solution, depending on tolerance, in place of glucose solutions. Controls (DD) received their usual therapy with glucose dialysate. Fifty-four DAA and 51 DD patients completed the study. In DAA, but not in DD patients, there was a significant increase at month 3 in serum insulin-like growth factor-1 (IGF-1) levels and significant decreases in serum potassium (all 3 months) and inorganic phosphorus levels (months 1 and 3), indicating a general anabolic response. Prealbumin and transferrin levels were significantly increased in DAA but not in DD patients at month 1, but the groups did not differ at months 2 and 3. In patients with baseline albumin levels less than 3.5 g/dL (bromcresol green [BCG] method), DAA patients showed increases in albumin, transferrin (months 1 and 2), and prealbumin levels (all 3 months) relative to baseline values, whereas these serum protein levels were unchanged in DD patients, although the changes from baseline did not differ between groups. In this subgroup, midarm muscle circumference (MAMC) did not change in DD or DAA patients. In patients with baseline albumin levels of 3.5 g/dL or greater, DD patients had decreases in albumin and total protein levels at all 3 months and in prealbumin levels at months 1 and 2, relative to baseline. In DAA patients, there were fewer changes in serum proteins. MAMC increased significantly from baseline in DAA but not in DD patients, although changes from baseline did not differ between DAA and DD groups. DAA patients showed no changes in peritoneal membrane transport characteristics. The results indicate that treatment with one or two exchanges daily of this amino acid-based PD solution is safe and provides nutritional benefit for malnourished PD patients. (Am J Kidney Dis 1998 Nov;32(5):761-9)