The pattern of myelin proteins in triethyltin (TET) intoxication

• Published in: Experimental pathology (1981) Vol. 23; no. 3; p. 193
• Main Authors: Wender, M, Zgorzalewicz, B, Piechowski, A, Spieszalski, W, Bucholc, M
• Format: Journal Article
• Language: English
• Published: Germany 1983
• Subjects: Animals; Myelin Basic Protein - analysis; Myelin Proteins - analysis; Myelin Sheath - analysis; Myelin Sheath - pathology; Nerve Fibers, Myelinated - pathology; Optic Nerve - analysis; Optic Nerve - pathology; Rats; Rats, Inbred Strains; Trialkyltin Compounds - poisoning; Triethyltin Compounds - poisoning; Vacuoles - ultrastructure
• ISSN: 0232-1513
• DOI: 10.1016/S0232-1513(83)80057-7

Myelin proteins isolated from the brain of Wistar rats intoxicated chronically with triethyltin sulfate (TET) according to the technique of ETO et al. (1971) were investigated. Among the various protein fractions, the Agraval protein happened to be most evidently affected, demonstrating considerably reduced percentages. However the results did not prove that any of the individual myelin proteins was specifically affected by TET intake. The interesting point in chronic TET poisoning was that some clinical symptoms as well as disturbances in myelin proteins demonstrated a clear tendency to retrogression despite of the continued intoxication. These observations indicate obviously that during chronic TET intake, some kind of biochemical adaptation to the noxious action of the poison on the myelin sheath takes place.