Hybrid Renal Cortical Imaging with Single Photon Emission Computerized Tomography/Computed Tomography in a Pediatric Patient with Severe Caudal Regression Syndrome

• Published in: Molecular imaging and radionuclide therapy Vol. 31; no. 1; pp. 69 - 71
• Main Authors: Kesim, Selin, Turoğlu, Halil Turgut, Özgüven, Salih, Öneş, Tunç, Erdil, Tanju Yusuf
• Format: Journal Article
• Language: English
• Published: Turkey Galenos Publishing House 01-02-2022; Galenos Publishing
• Subjects: Abnormalities; Anomalies; Anorectal; Computed tomography; Conflicts of interest; Consent; Diabetes mellitus; Dimercaptosuccinic acid; Interesting Image; Kidneys; Medical imaging; Pediatrics; Photon emission; Renal failure; Sacrum; Scintigraphy; Technetium; Technetium isotopes; Tomography; Trachea; Ureter; Vertebrae; sacral agenesis; Caudal regression syndrome; Tc-99m DMSA renal scintigraphy; SPECT/CT; VACTERL association
• ISSN: 2146-1414; 2147-1959
• DOI: 10.4274/mirt.galenos.2020.84755

Caudal regression syndrome (CRS) or sacral agenesis is a rarely seen malformation with a varying degree of structural abnormalities, including multiorgan system dysfunctions, reported with higher incidence among children of mothers with diabetes, as in this case. Spinal anomalies can range from coccyx hemiagenesis to the total absence of lower lumbar vertebrae and sacrum in most severe cases. Herein, we have presented a 9-year-old patient with CRS who had renal failure. Technetium-99m dimercaptosuccinic acid renal scintigraphy revealed bilaterally non-functioning kidneys with no renal cortical uptake. Renal anomalies in CRS with vertebral, anorectal, cardiac, trachea-esophageal, renal, and limb anomalies association include one-sided renal agenesis, multicystic dysplastic kidneys, and ureter duplications.